Sandeep Robert Datta
Sandeep Robert Datta, MD, PhD
Professor of Neurobiology

Animals in the wild engage with the environment through complex self-directed behaviors. Brains then build internal cognitive models that enable useful predictions about the statistical structure of the world. However, the role that naturalistic behavior plays in shaping cognitive models has remained unclear. The Datta lab wishes to address how the brain uses sensation to inform action, how the brain uses action to more effectively sense the world, and how the brain integrates information about sensation and action to meaningfully interact with the environment. The main hypothesis of the laboratory is that we can gain leverage on this set of problems by studying neural circuits that underlie spontaneously-generated behaviors in unrestrained animals — in other words, by exploring neural circuits in which sensation and ongoing action are necessarily intertwined. Given that olfaction is the primary sense used by most animals to communicate with their environment, we focus on characterizing odor information as it propagates through the olfactory system to drive complex solitary and social behaviors and facilitate learning. Conversely, we ask how motor systems interpret organized representations of the sensory environment to compose ongoing, moment-to-moment behavioral sequences that aid in understanding the sensory environment and ultimately allow animals to survive in a complex world.

Publications View
Pseudotumor Cerebri Syndrome With COVID-19: A Case Series.
Authors: Authors: Mukharesh L, Bouffard MA, Fortin E, Brann DH, Datta SR, Prasad S, Chwalisz BK.
J Neuroophthalmol
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Persistent post-COVID-19 smell loss is associated with inflammatory infiltration and altered olfactory epithelial gene expression.
Authors: Authors: Finlay JB, Brann DH, Abi-Hachem R, Jang DW, Oliva AD, Ko T, Gupta R, Wellford SA, Moseman EA, Jang SS, Yan CH, Matusnami H, Tsukahara T, Datta SR, Goldstein BJ.
bioRxiv
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A transcriptional rheostat couples past activity to future sensory responses.
Authors: Authors: Tsukahara T, Brann DH, Pashkovski SL, Guitchounts G, Bozza T, Datta SR.
Cell
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GABA-receptive microglia selectively sculpt developing inhibitory circuits.
Authors: Authors: Favuzzi E, Huang S, Saldi GA, Binan L, Ibrahim LA, Fernández-Otero M, Cao Y, Zeine A, Sefah A, Zheng K, Xu Q, Khlestova E, Farhi SL, Bonneau R, Datta SR, Stevens B, Fishell G.
Cell
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GABA-receptive microglia selectively sculpt developing inhibitory circuits.
Authors: Authors: Favuzzi E, Huang S, Saldi GA, Binan L, Ibrahim LA, Fernández-Otero M, Cao Y, Zeine A, Sefah A, Zheng K, Xu Q, Khlestova E, Farhi SL, Bonneau R, Datta SR, Stevens B, Fishell G.
Cell
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Internal state: dynamic, interconnected communication loops distributed across body, brain, and time.
Authors: Authors: Kanwal JK, Coddington E, Frazer R, Limbania D, Turner G, Davila KJ, Givens MA, Williams V, Datta SR, Wasserman S.
Integr Comp Biol
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Flexible scaling and persistence of social vocal communication.
Authors: Authors: Chen J, Markowitz JE, Lilascharoen V, Taylor S, Sheurpukdi P, Keller JA, Jensen JR, Lim BK, Datta SR, Stowers L.
Nature
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Systems Neuroscience of Natural Behaviors in Rodents.
Authors: Authors: Dennis EJ, El Hady A, Michaiel A, Clemens A, Gowan Tervo DR, Voigts J, Datta SR.
J Neurosci
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Cerebellum-Specific Deletion of the GABAA Receptor d Subunit Leads to Sex-Specific Disruption of Behavior.
Authors: Authors: Rudolph S, Guo C, Pashkovski SL, Osorno T, Gillis WF, Krauss JM, Nyitrai H, Flaquer I, El-Rifai M, Datta SR, Regehr WG.
Cell Rep
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Revealing the structure of pharmacobehavioral space through motion sequencing.
Authors: Authors: Wiltschko AB, Tsukahara T, Zeine A, Anyoha R, Gillis WF, Markowitz JE, Peterson RE, Katon J, Johnson MJ, Datta SR.
Nat Neurosci
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