The Charles R. Broderick III Phytocannabinoid Research Initiative supports basic and translational research that will advance our understanding of how cannabinoids impinge on nervous system function and behavior. The goal of the program is to generate novel insights into the neurobiology of cannabis and cannabinoids. Successful proposals will focus on highly creative research programs relevant to our understanding of the molecular, cellular, and behavioral effects of cannabis use on the nervous system, the biology of brain systems that respond to cannabis and cannabinoids, and studies that lay the foundation for clinical application of cannabinoids.
The Phytocannabinoid Research Initiative supports proposals for independent or collaborative Faculty Research Grants as well as Predoctoral / Postdoctoral Fellowships.
The 2019 application program is closed. The next RFAs will be released in December 2020-January 2021.
The 2019 Faculty awardees are:
Todd Anthony (Boston Children's Hospital) and Patrick Fuller (Beth Israel): Cannabidiol modulation of neural circuits that control anxiety and sleep
Bruce Bean (HMS Neurobiology): Inhibition of neuronal excitability by cannabidiol and other phytocannabinoids
Staci Gruber (McLean): Consider the Source: Examining the Impact of a Full-Spectrum vs a Single-Compound Cannabinoid Product on Clinical, Cognitive, and Neurobiologic Outcomes
Hisashi Umemori (Boston Children's Hospital): Pathway-specific effects of early-life cannabis exposure on dopamine synapse development
The 2019 Fellowship awardees are:
Phillip Aschauer (lab of Mahmoud Nasr, HMS Biological Chemistry and Molecular Pharmacology): A novel method for formation and structural studies of GPCR heterodimers
Daniel Taub (lab of Clifford Woolf, Boston Children's Hospital): The Role of Phytocannabinoids in the Emotional Aspects of Pain
Meng Zhang (lab of Gerhard Wagner, HMS Biological Chemistry and Molecular Pharmacology): Structure and dynamics of the cannabinoid receptors in complex with phytocannabinoids and G protein trimer