Evan Macosko

Evan Macosko, MD, PhD

Associate Professor in the Departments of Psychiatry and Neurobiology at Harvard Medical School

Edward Scolnick Professor of the Broad Institute of MIT and Harvard

Research
Publications

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Evan Macosko, MD, PhD – Faculty Profile

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Title: Associate Professor in the Departments of Psychiatry and Neurobiology at Harvard Medical School; Edward Scolnick Professor of the Broad Institute of MIT and Harvard.

The Aim

The Macosko Lab maps the diversity and gene activity of brain cells to reveal how their changes drive behavior, development, and neuropsychiatric diseases.

The Impact

The Macosko Lab uncovers the incredible diversity of brain cells and how they work together to drive behavior and health. By developing breakthrough technologies to map thousands of different cell types and track their gene activity at the single-cell level, the lab reveals how cellular changes contribute to brain development and neuropsychiatric diseases like depression or schizophrenia. Their work could lead to better models and new treatments by pinpointing which brain cells go awry in disease.

A Closer Look

Article: A very specific kind of brain cell dies off in people with Parkinson’s , Science News, May 2022. The article suggests that dopamine neurons may die because they are chronically overactive and “burn out,” pointing to the cells’ excessive workload—as a key driver of degeneration and a potential treatment target.

Article: Early Alzheimer’s Secrets Unveiled in Brain Tissue Study , Technology Networks, October 2023. The article reports on a study of brain tissue from living adults that reveals very early cellular changes and specific brain cell types involved in Alzheimer’s disease, offering new clues about how plaques form and neurons begin to die.

Contact

Email: EMacosko@broadinstitute.org

Lab website: macoskolab.com

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Publications View