Clifford Woolf
Clifford Woolf, MB, BCh, PhD
Professor of Neurology

Our group is devoted to investigating the way in which the functional, chemical and structural plasticity of neurons contributes both to the normal function and diseases of the nervous system. Major efforts are devoted to the study of pain, regeneration and neurodegenerative diseases. Most of our work is concentrated on primary sensory and motor neurons, and to the interaction of neurons and immune cells, using a multidisciplinary approach spanning stem cell, molecular and cell biology, electrophysiology, neuroanatomy, behavior and genetics. We have established functional and comparative genomic strategies using expression profiling, bioinformatics and gain- and loss-of-function approaches, to screen for novel genes that contribute to neuronal plasticity and disease phenotypes. The group works closely with many academic groups and the pharmaceutical industry to model disease and identify molecular targets for novel analgesics, axonal growth determinants and neuroprotective agents. Current research includes study of the transcriptional control and post-translational processing of receptors and ion channels that mediate pain hypersensitivity, selective silencing of defined neuronal populations, intracellular signal transduction cascades activated by peripheral inflammation and nerve injury, neuro-immune interactions, transcription factors as master regulators of pain, growth and survival programs, cell survival in injured sensory and motor neurons, and the contribution of intrinsic growth determinants in establishing regenerative capacity in the peripheral and central nervous system. We are an active part of the Harvard Stem Cell Institute and are investigating how sensory and motor neurons reprogrammed from patient fibroblasts can be used to study pain and motor neuron disease and to screen for new treatments.

 

"We have established functional and comparative genomic strategies using expression profiling, bioinformatics and gain- and loss-of-function approaches, to screen for novel genes that contribute to neuronal plasticity and disease phenotypes."

Publications View
Macrophages set the bar for acute pain sensitivity.
Authors: Authors: Hakim S, Woolf CJ.
Nat Immunol
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Nociceptor neuroimmune interactomes reveal cell type- and injury-specific inflammatory pain pathways.
Authors: Authors: Jain A, Gyori BM, Hakim S, Bunga S, Taub DG, Ruiz-Cantero MC, Tong-Li C, Andrews N, Sorger PK, Woolf CJ.
bioRxiv
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Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells.
Authors: Authors: Tian F, Cheng Y, Zhou S, Wang Q, Monavarfeshani A, Gao K, Jiang W, Kawaguchi R, Wang Q, Tang M, Donahue R, Meng H, Zhang Y, Jacobi A, Yan W, Yin J, Cai X, Yang Z, Hegarty S, Stanicka J, Dmitriev P, Taub D, Zhu J, Woolf CJ, Sanes JR, Geschwind DH, He Z.
Neuron
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ß-Endorphin mediates radiation therapy fatigue.
Authors: Authors: Hermann AL, Fell GL, Kemény LV, Fung CY, Held KD, Biggs PJ, Rivera PD, Bilbo SD, Igras V, Willers H, Kung J, Gheorghiu L, Hideghéty K, Mao J, Woolf CJ, Fisher DE.
Sci Adv
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Structural imaging studies of patients with chronic pain: an anatomic likelihood estimate meta-analysis.
Authors: Authors: Henn AT, Larsen B, Frahm L, Xu A, Adebimpe A, Scott JC, Linguiti S, Sharma V, Basbaum AI, Corder G, Dworkin RH, Edwards RR, Woolf CJ, Habel U, Eickhoff SB, Eickhoff CR, Wagels L, Satterthwaite TD.
Pain
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Automated preclinical detection of mechanical pain hypersensitivity and analgesia.
Authors: Authors: Zhang Z, Roberson DP, Kotoda M, Boivin B, Bohnslav JP, González-Cano R, Yarmolinsky DA, Lenfers Turnes R, Wimalasena NK, Neufeld SQ, Barrett L, Quintão NLM, Fattori V, Taub DG, Wiltschko AB, Andrews N, Harvey CD, Datta SR, Woolf CJ.
Pain
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Cannabidiol activates neuronal Kv7 channels.
Authors: Authors: Zhang HB, Heckman L, Niday Z, Jo S, Fujita A, Shim J, Pandey R, Al Jandal H, Jayakar S, Barrett LB, Smith J, Woolf CJ, Bean BP.
Elife
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A Multiparametric Activity Profiling Platform for Neuron Disease Phenotyping and Drug Screening.
Authors: Authors: Boivin B, Roet KCD, Huang X, Karhohs KW, Rohban MH, Sandoe J, Wiskow O, Maeda R, Grantham A, Dornon MK, Shao J, Frost D, Baker D, Eggan K, Carpenter AE, Woolf CJ.
Mol Biol Cell
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Developing nociceptor-selective treatments for acute and chronic pain.
Authors: Authors: Jayakar S, Shim J, Jo S, Bean BP, Singeç I, Woolf CJ.
Sci Transl Med
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Nociceptor neurons promote IgE class switch in B cells.
Authors: Authors: Mathur S, Wang JC, Seehus CR, Poirier F, Crosson T, Hsieh YC, Doyle B, Lee S, Woolf CJ, Foster SL, Talbot S.
JCI Insight
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