Wade Regehr

Wade Regehr, Ph.D.

Bullard Professor of Neurobiology, Harvard Medical School

Synaptic Plasticity and Cerebellar Function

The lab studies diverse topics ranging from the control of neurotransmitter release to the behavioral roles of the cerebellum.  Synaptic plasticity has been a long-standing interest of the lab. In recent years we have focused on the molecular control of release kinetics and short-term synaptic plasticity, and the functional and behavioral roles of these synaptic properties.  We also study the cerebellum.  It is increasingly apparent that the cerebellar circuit and behavioral roles of the cerebellum are much more complex than previously appreciated.  Our studies clarify circuitry, and provide insights into how the cerebellum controls various behaviors, and how cerebellar disfunction leads to neurological disorders such as autism.

Publications View
Characterization of direct Purkinje cell outputs to the brainstem.
Authors: Authors: Chen CH, Yao Z, Wu S, Regehr WG.
bioRxiv
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Realistic mossy fiber input patterns to unipolar brush cells evoke a continuum of temporal responses comprised of components mediated by different glutamate receptors.
Authors: Authors: Huson V, Regehr WG.
bioRxiv
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Specialized connectivity of molecular layer interneuron subtypes leads to disinhibition and synchronous inhibition of cerebellar Purkinje cells.
Authors: Authors: Lackey EP, Moreira L, Norton A, Hemelt ME, Osorno T, Nguyen TM, Macosko EZ, Lee WA, Hull CA, Regehr WG.
Neuron
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Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs.
Authors: Authors: Wu S, Wardak A, Khan MM, Chen CH, Regehr WG.
Elife
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A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain.
Authors: Authors: Chen CH, Newman LN, Stark AP, Bond KE, Zhang D, Nardone S, Vanderburg CR, Nadaf NM, Yao Z, Mutume K, Flaquer I, Lowell BB, Macosko EZ, Regehr WG.
Nat Neurosci
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Cerebellar circuits for disinhibition and synchronous inhibition.
Authors: Authors: Lackey EP, Moreira L, Norton A, Hemelt ME, Osorno T, Nguyen TM, Macosko EZ, Lee WA, Hull CA, Regehr WG.
bioRxiv
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A continuum of response properties across the population of Unipolar Brush Cells in the Dorsal Cochlear Nucleus.
Authors: Authors: Huson V, Newman LN, Regehr WG.
J Neurosci
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Cerebellar granule cell signaling is indispensable for normal motor performance.
Authors: Authors: Lee JH, Khan MM, Stark AP, Seo S, Norton A, Yao Z, Chen CH, Regehr WG.
Cell Rep
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Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs.
Authors: Authors: Wu S, Wardak A, Khan MM, Chen CH, Regehr WG.
bioRxiv
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Publisher Correction: Structured cerebellar connectivity supports resilient pattern separation.
Authors: Authors: Nguyen TM, Thomas LA, Rhoades JL, Ricchi I, Yuan XC, Sheridan A, Hildebrand DGC, Funke J, Regehr WG, Lee WA.
Nature
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