Portrait of a woman with shoulder-length wavy brown hair, wearing a dark blue top, against a softly blurred indoor background.

Lisa Goodrich, Ph.D.

Professor of Neurobiology, Harvard Medical School
Vice Chair of Neurobiology, Harvard Medical School

Lisa Goodrich, PhD – People Feature

Professor of Neurobiology and Department Vice Chair in the Department of Neurobiology at Harvard Medical School.

If you prefer, you can view the visual layout directly on Canva by Neuro Coordinator.

Contact

Email: lisa_goodrich@hms.harvard.edu

Goodrich Lab website: goodrich.med.harvard.edu

The Goal

The Goodrich Lab studies how hearing circuits form and function, and what leads to their deterioration.

The Impact

Studying how the brain and ear work together to produce our sense of hearing offers insight into a key sensory system that people and animals use to navigate the world.

Hearing can be impaired by genetic mutations, infection, or exposure to excessively loud sounds. Deciphering the cellular and molecular mechanisms underlying the formation and function of auditory circuits may lead to improved protection of hearing and treatments for hearing loss.

This work has the potential to help people of all ages more fully enjoy the sounds that enrich our lives.

A Closer Look

Harvard Medicine Magazine — Spring 2020: 5 Questions with a Neurobiologist: A Conversation with Lisa Goodrich

Lisa reflects on the rewards and challenges of life as a researcher and offers advice for others interested in pursuing scientific research. She discusses the molecular origins of sensory circuits, the rewards of scientific discovery, and the importance of flexibility in research and career paths.

Harvard Medical School News — November 2011: Bioengineering for Hearing, Sight and Mobility

Dr. Goodrich presented her research at the inaugural Bertarelli Neuroengineering Symposium in Lausanne, Switzerland. Support from the Bertarelli Foundation funded a project in her lab with the potential to help people whose lives are affected by hearing loss.

The featured research focuses on understanding auditory hair cells and developing approaches that could support improved treatments for hearing loss.

Publications View
Principles of planar polarity in animal development.
Authors: Authors: Goodrich LV, Strutt D.
Development
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Spatiotemporal fate map of neurogenin1 (Neurog1) lineages in the mouse central nervous system.
Authors: Authors: Kim EJ, Hori K, Wyckoff A, Dickel LK, Koundakjian EJ, Goodrich LV, Johnson JE.
J Comp Neurol
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Connecting the ear to the brain: Molecular mechanisms of auditory circuit assembly.
Authors: Authors: Appler JM, Goodrich LV.
Prog Neurobiol
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Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis.
Authors: Authors: Abraira VE, Satoh T, Fekete DM, Goodrich LV.
PLoS One
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Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear.
Authors: Authors: Abraira VE, Del Rio T, Tucker AF, Slonimsky J, Keirnes HL, Goodrich LV.
Development
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The plane facts of PCP in the CNS.
Authors: Authors: Goodrich LV.
Neuron
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Auditory neurons make stereotyped wiring decisions before maturation of their targets.
Authors: Authors: Koundakjian EJ, Appler JL, Goodrich LV.
J Neurosci
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Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development.
Authors: Authors: Raft S, Koundakjian EJ, Quinones H, Jayasena CS, Goodrich LV, Johnson JE, Segil N, Groves AK.
Development
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Changes in Sef levels influence auditory brainstem development and function.
Authors: Authors: Abraira VE, Hyun N, Tucker AF, Coling DE, Brown MC, Lu C, Hoffman GR, Goodrich LV.
J Neurosci
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Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear.
Authors: Authors: Deans MR, Antic D, Suyama K, Scott MP, Axelrod JD, Goodrich LV.
J Neurosci
View full abstract on Pubmed