Jan Drugowitsch

Jan Drugowitsch, Ph.D.

Associate Professor of Neurobiology, Harvard Medical School

Connecting Brain and Mind through Computational Neuroscience

Every decision and behavior is haunted by uncertainty, introduced by the noisy and ambiguous nature of the world that surrounds us. Despite this, we make such decisions with seeming ease. The goal of the Drugowitsch Lab is to understand the fundamental computations and their neurobiological implementations that allow the nervous system to support such efficient behavior.

By using tools from artificial intelligence and neuroscience research, we approach this goal by developing theories about how the networks of neurons in our brains are able to infer, represent, and process the state of the world, and how this processing leads to decisions we make on a daily basis.

Our current research focuses on decisions based on evidence we directly observe, rather than memorized knowledge. We have previously shown that, in this context, decision-makers are able to trade off the time they contemplate such decisions with their accuracy in a close-to-optimal manner. We are further asking how decision strategies change once these decisions are between options of different intrinsic values, and what might be the computations involved to make up one’s mind about these values. In the close future, we plan on extending our investigations not only to decisions that require taking into account the more complex structure of every-day visual scenes, but also to address behavior of higher dimensions, such as spatial navigation under uncertainty.

Publications View
Competitive integration of time and reward explains value-sensitive foraging decisions and frontal cortex ramping dynamics.
Authors: Authors: Bukwich M, Campbell MG, Zoltowski D, Kingsbury L, Tomov MS, Stern J, Kim HR, Drugowitsch J, Linderman SW, Uchida N.
Neuron
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Distributed control circuits across a brain-and-cord connectome.
Authors: Authors: Bates AS, Phelps JS, Kim M, Yang HH, Matsliah A, Ajabi Z, Perlman E, Delgado KM, Osman MAM, Salmon CK, Gager J, Silverman B, Renauld S, Collie MF, Fan J, Pacheco DA, Zhao Y, Patel J, Zhang W, Serratosa Capdevilla L, Roberts RJV, Munnelly EJ, Griggs N, Langley H, Moya-Llamas B, Maloney RT, Yu SC, Sterling AR, Sorek M, Kruk K, Serafetinidis N, Dhawan S, Stürner T, Klemm F, Brooks P, Lesser E, Jones JM, Pierce-Lundgren SE, Lee SY, Luo Y, Cook AP, McKim TH, Kophs EC, Falt T, Negrón Morales AM, Burke A, Hebditch J, Willie KP, Willie R, Popovych S, Kemnitz N, Ih D, Lee K, Lu R, Halageri A, Bae JA, Jourdan B, Schwartzman G, Demarest DD, Behnke E, Bland D, Kristiansen A, Skelton J, Stocks T, Garner D, Salman F, Daly KC, Hernandez A, Kumar S, Dorkenwald S, Collman F, Suver MP, Fenk LM, Pankratz MJ, Jefferis GSXE, Eichler K, Seeds AM, Hampel S, Agrawal S, Zandawala M, Macrina T, Adjavon DY, Funke J, Tuthill JC, Azevedo A, Seung HS, de Bivort BL, Murthy M, Drugowitsch J, Wilson RI, Lee WA.
bioRxiv
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Multimodal cue integration and learning in a neural representation of head direction.
Authors: Authors: Basnak MA, Kutschireiter A, Okubo TS, Chen A, Gorelik P, Drugowitsch J, Wilson RI.
Nat Neurosci
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A unifying theory of receptive field heterogeneity predicts hippocampal spatial tuning.
Authors: Authors: Cohen Z, Drugowitsch J.
bioRxiv
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Hierarchical Vector Analysis of Visual Motion Perception.
Authors: Authors: Gershman SJ, Bill J, Drugowitsch J.
Annu Rev Vis Sci
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An opponent striatal circuit for distributional reinforcement learning.
Authors: Authors: Lowet AS, Zheng Q, Meng M, Matias S, Drugowitsch J, Uchida N.
Nature
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Nerve injury disrupts temporal processing in the spinal cord dorsal horn through alterations in PV+ interneurons.
Authors: Authors: Rankin G, Chirila AM, Emanuel AJ, Zhang Z, Woolf CJ, Drugowitsch J, Ginty DD.
Cell Rep
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An opponent striatal circuit for distributional reinforcement learning.
Authors: Authors: Lowet AS, Zheng Q, Meng M, Matias S, Drugowitsch J, Uchida N.
bioRxiv
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Stochastic Optimal Control and Estimation with Multiplicative and Internal Noise.
Authors: Authors: Damiani F, Anzai A, Drugowitsch J, DeAngelis GC, Moreno-Bote R.
Adv Neural Inf Process Syst
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Causal inference during closed-loop navigation: parsing of self- and object-motion.
Authors: Authors: Noel JP, Bill J, Ding H, Vastola J, DeAngelis GC, Angelaki DE, Drugowitsch J.
Philos Trans R Soc Lond B Biol Sci
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