Portrait of a smiling man with white hair and round glasses, wearing a pink patterned shirt against a light-colored wall.

Gord Fishell, Ph.D.

Professor of Neurobiology, Harvard Medical School

Accessible description of graphic: One-page profile titled “Gord Fishell, Ph.D.” with the subtitle “Professor of Neurobiology, Harvard Medical School.” At the top right is a portrait photo of Gord Fishell. Under the title there are two circular buttons: one linking to his email address and one to his laboratory website. The email button links to gordon_fishell@hms.harvard.edu and the lab button links to fishelllab.hms.harvard.edu .

Under the heading “The Aim”, the text reads: “The Fishell Lab investigates how inhibitory interneurons, the brain's primary gating system of information flow, are generated and integrated into circuits during development.”

Under the heading “The Impact”, the text explains that brain function depends on a balance between excitation and inhibition, and that inhibitory interneurons are responsible for maintaining that balance. The Fishell Lab’s research reveals a remarkable diversity of interneuron subtypes, each with its own shape, connectivity, and function. Mapping the developmental origins of interneuron diversity is opening new avenues for therapeutic approaches to conditions such as autism and schizophrenia.

A section titled “A Closer Look” highlights two featured studies. The first is labeled “Nature – May 2026” and is illustrated with a multipanel figure. The caption explains that this paper discusses new research that pinpoints a specific set of brain cells in mice that rapidly detect danger and convert signals from memory and emotion centers into defensive actions such as freezing or escaping. You can read this article at the related Nature publication (external link) .

The second featured item is labeled “Harvard Medical School – December 2021”, with an illustration titled “The Brain’s Wiring Technicians.” The text explains that Gord Fishell’s team discovered a specialized subset of microglia—immune cells in the brain—that home in on and selectively “prune” inhibitory synapses via GABA receptors. This pruning helps balance excitation and inhibition in developing circuits and suggests new ways to fix miswired brain networks in disorders such as autism, ADHD, and schizophrenia. A related article can be accessed at the Harvard Medical School feature on this research (external link) .

At the bottom, the graphic repeats his role and contact information: “Gord Fishell, Ph.D., Professor of Neurobiology, Harvard Medical School”, with the email gordon_fishell@hms.harvard.edu and the lab website fishelllab.hms.harvard.edu .

Publications View
Pyramidal neurons proportionately alter the identity and survival of specific cortical interneuron subtypes.
Authors: Authors: Wu SJ, Dai M, Yang SP, McCann C, Qiu Y, Marrero GJ, Stogsdill JA, Di Bella DJ, Xu Q, Farhi SL, Macosko EZ, Che F, Fishell G.
Res Sq
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Interneuron Diversity: How Form Becomes Function.
Authors: Authors: De Marco García NV, Fishell G.
Cold Spring Harb Perspect Biol
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An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes.
Authors: Authors: Furlanis E, Dai M, Leyva Garcia B, Vergara J, Pereira A, Pelkey K, Tran T, Gorissen BL, Vlachos A, Hairston A, Huang S, Dwivedi D, Du S, Wills S, McMahon J, Lee AT, Chang EF, Razzaq T, Qazi A, Vargish G, Yuan X, Caccavano A, Hunt S, Chittajallu R, McLean N, Hewit L, Paranzino E, Rice H, Cummins AC, Plotnikova A, Mohanty A, Tangen AC, Shin JH, Azadi R, Eldridge MAG, Alvarez VA, Averbeck BB, Alyahyay M, Reyes Vallejo T, Soheib M, Vattino LG, MacGregor CP, Banks E, Olah VJ, Naskar S, Hill S, Liebergall S, Badiani R, Hyde L, Xu Q, Allaway KC, Goldberg EM, Nowakowski TJ, Lee S, Takesian AE, Ibrahim LA, Iqbal A, McBain CJ, Dimidschstein J, Fishell G, Wang Y.
bioRxiv
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Pyramidal neurons proportionately alter the identity and survival of specific cortical interneuron subtypes.
Authors: Authors: Wu SJ, Dai M, Yang SP, McCann C, Qiu Y, Marrero GJ, Stogsdill JA, Di Bella DJ, Xu Q, Farhi SL, Macosko EZ, Chen F, Fishell G.
bioRxiv
View full abstract on Pubmed
Neurogliaform Cells Exhibit Laminar-specific Responses in the Visual Cortex and Modulate Behavioral State-dependent Cortical Activity.
Authors: Authors: Huang S, Rizzo D, Wu SJ, Xu Q, Ziane L, Alghamdi N, Stafford DA, Daigle TL, Tasic B, Zeng H, Ibrahim LA, Fishell G.
Res Sq
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Metabotropic signaling within somatostatin interneurons controls transient thalamocortical inputs during development.
Authors:
Nat Commun
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Neurogliaform Cells Exhibit Laminar-specific Responses in the Visual Cortex and Modulate Behavioral State-dependent Cortical Activity.
Authors:
bioRxiv
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Developmental trajectories of GABAergic cortical interneurons are sequentially modulated by dynamic FoxG1 expression levels.
Authors: Authors: Miyoshi G, Ueta Y, Yagasaki Y, Kishi Y, Fishell G, Machold RP, Miyata M.
Proc Natl Acad Sci U S A
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Disruption of Cholinergic Retinal Waves Alters Visual Cortex Development and Function.
Authors: Authors: Burbridge TJ, Ratliff JM, Dwivedi D, Vrudhula U, Alvarado-Huerta F, Sjulson L, Ibrahim LA, Cheadle L, Fishell G, Batista-Brito R.
bioRxiv
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An Anatomical and Physiological Basis for Coincidence Detection Across Time Scales in the Auditory System.
Authors: Authors: Kreeger LJ, Honnuraiah S, Maeker S, Shea S, Fishell G, Goodrich LV.
bioRxiv
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