Christopher D. Harvey, Ph.D.
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Christopher Harvey, PhD
Professor of Neurobiology
Department of Neurobiology, Harvard Medical School
Email:
christopher_harvey@hms.harvard.edu
Website:
Harvey Lab website – more information about Christopher Harvey’s research (opens in a new tab)
The Aim
The Harvey Lab studies how brain circuits guide navigation, memory, and decision‑making.
The Impact
Finding your way from point A to point B requires the brain to integrate memory, sensory information, and ongoing decisions in real time. The Harvey Lab uses virtual‑reality environments and advanced imaging tools to watch these computations unfold in living neural circuits, identifying the specific cell types and connection patterns that make them possible. Because working memory and navigation are impaired in Alzheimer’s disease, schizophrenia, and traumatic brain injury, this research lays important groundwork for understanding what goes wrong in such conditions, and what interventions might be possible.
A Closer Look
MedicalXpress – February 2024: Mapping decision‑making circuits in the brain (article, opens in a new tab)
This article covers Harvey’s research, published in Nature, which maps the physical connections between decision‑making neurons. This study found that choosing to go left or right activates a chain of cells that ultimately suppresses the neural pathway for the alternative choice, a concrete synaptic mechanism behind how the brain commits to a decision.
ScienceDaily – July 2023: Error‑correction signals in a navigating brain (article, opens in a new tab)
The Harvey Lab placed mice in a virtual‑reality maze and identified a specific type of inhibitory neuron that fires precisely when an animal makes, and then corrects, a wrong turn. This marks the first time an error‑correction signal has been pinpointed in a navigating brain.
bioRxiv
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Nat Neurosci
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Cell Rep
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Adv Neural Inf Process Syst
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bioRxiv
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Nat Commun
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Nature
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bioRxiv
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Nature
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Nat Commun
View full abstract on Pubmed