Bernardo Sabatini

Bernardo Sabatini, M.D., Ph.D.

Alice and Rodman W. Moorhead III Professor of Neurobiology, Harvard Medical School
Co-Director of the Kempner Institute for the Study of Natural and Artificial Intelligence at Harvard University, Harvard University

Synapse Function and Animal Behavior

In the first few years of life, humans tremendously expand their behavioral repertoire and gain the ability to engage in complex, learned, and reward-driven actions. Similarly, within a few weeks after birth mice can perform sophisticated spatial navigation, forage independently for food, and engage in reward reinforcement learning.

The Sabatini lab seeks to uncover the mechanisms of synapse and circuit plasticity that permit new behaviors to be learned and refined. We are interested in the developmental changes that occur after birth that make learning possible as well as in the circuit changes that are triggered by the process of learning.  Lastly, we examine how perturbations of these processes contribute to human neuropsychiatric disorders such as Tuberous Sclerosis Complex and Parkinson’s Disease.

Publications View
Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration.
Authors: Authors: Hochbaum DR, Hulshof L, Urke A, Wang W, Dubinsky AC, Farnsworth HC, Hakim R, Lin S, Kleinberg G, Robertson K, Park C, Solberg A, Yang Y, Baynard C, Nadaf NM, Beron CC, Girasole AE, Chantranupong L, Cortopassi MD, Prouty S, Geistlinger L, Banks AS, Scanlan TS, Datta SR, Greenberg ME, Boulting GL, Macosko EZ, Sabatini BL.
Cell
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Explaining dopamine through prediction errors and beyond.
Authors: Authors: Gershman SJ, Assad JA, Datta SR, Linderman SW, Sabatini BL, Uchida N, Wilbrecht L.
Nat Neurosci
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Mixed representations of choice and outcome by GABA/glutamate cotransmitting neurons in the entopeduncular nucleus.
Authors:
bioRxiv
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Comment on 'Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation'.
Authors: Authors: Taniguchi J, Melani R, Chantranupong L, Wen MJ, Mohebi A, Berke JD, Sabatini BL, Tritsch NX.
Elife
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A Cre-dependent reporter mouse for quantitative real-time imaging of protein kinase A activity dynamics.
Authors: Authors: Tilden EI, Maduskar A, Oldenborg A, Sabatini BL, Chen Y.
Sci Rep
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Longevity, demographic characteristics, and socio-economic status are linked to triiodothyronine levels in the general population.
Authors: Authors: Lawton RI, Sabatini BL, Hochbaum DR.
Proc Natl Acad Sci U S A
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Comment on 'Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation'.
Authors: Authors: Taniguchi J, Melani R, Chantranupong L, Wen MJ, Mohebi A, Berke J, Sabatini B, Tritsch N.
bioRxiv
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Cortical reactivations predict future sensory responses.
Authors: Authors: Nguyen ND, Lutas A, Amsalem O, Fernando J, Ahn AY, Hakim R, Vergara J, McMahon J, Dimidschstein J, Sabatini BL, Andermann ML.
Nature
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Striatum supports fast learning but not memory recall.
Authors: Authors: Reinhold K, Iadarola M, Tang S, Kuwamoto W, Sun S, Hakim R, Zimmer J, Wang W, Sabatini BL.
bioRxiv
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A Cre-dependent reporter mouse for quantitative real-time imaging of Protein Kinase A activity dynamics.
Authors: Authors: Tilden EI, Maduskar A, Oldenborg A, Sabatini BL, Chen Y.
bioRxiv
View full abstract on Pubmed