Bernardo Sabatini
Bernardo Sabatini, MD, PhD
Alice and Rodman W. Moorhead III Professor of Neurobiology

The main focus of my research laboratory is to understand the development and regulation of synapses in the brain and the relationship of these processes to behavior and disease.  Our studies include analysis of:

  1. The biophysical processes that control the function of individual synapses
  2. The mechanisms of regulation of synapses and neurons by neuromodulators such as dopamine, acetylcholine, and peptides
  3. The relationship between synaptic plasticity and behavior
  4. The role of perturbed synapse function in human neuropsychiatric diseases such as autism, Parkinson’s and Alzheimer’s

Our studies are performed in the mammalian brain and we focus on the analysis of hippocampus, cortex, and basal ganglia.  Recently, the analysis of the basal ganglia has become a major focus of the laboratory and we hope to perform a comprehensive analysis of the questions above in this brain structure.  Lastly, as necessary for our studies, we develop novel optical, electrophysiological, and behavioral approaches to carry out the proposed work. Greater detail and a complete list of publications can be found at our laboratory website.

 

"Recently, the analysis of the basal ganglia has become a major focus of the laboratory and we hope to perform a comprehensive analysis of the questions above in this brain structure."

Publications View
Cell-type-specific asynchronous modulation of PKA by dopamine in learning.
Authors: Authors: Lee SJ, Lodder B, Chen Y, Patriarchi T, Tian L, Sabatini BL.
Nature
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Imaging Neurotransmitter and Neuromodulator Dynamics In Vivo with Genetically Encoded Indicators.
Authors: Authors: Sabatini BL, Tian L.
Neuron
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Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain.
Authors: Authors: Chantranupong L, Saulnier JL, Wang W, Jones DR, Pacold ME, Sabatini BL.
Elife
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Anatomically segregated basal ganglia pathways allow parallel behavioral modulation.
Authors: Authors: Lee J, Wang W, Sabatini BL.
Nat Neurosci
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Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans.
Authors: Authors: Vormstein-Schneider D, Lin JD, Pelkey KA, Chittajallu R, Guo B, Arias-Garcia MA, Allaway K, Sakopoulos S, Schneider G, Stevenson O, Vergara J, Sharma J, Zhang Q, Franken TP, Smith J, Ibrahim LA, M Astro KJ, Sabri E, Huang S, Favuzzi E, Burbridge T, Xu Q, Guo L, Vogel I, Sanchez V, Saldi GA, Gorissen BL, Yuan X, Zaghloul KA, Devinsky O, Sabatini BL, Batista-Brito R, Reynolds J, Feng G, Fu Z, McBain CJ, Fishell G, Dimidschstein J.
Nat Neurosci
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Two-photon fluorescence-assisted laser ablation of non-planar metal surfaces: fabrication of optical apertures on tapered fibers for optical neural interfaces.
Authors: Authors: Balena A, Bianco M, Pisano F, Pisanello M, Sileo L, Sabatini BL, Vittorio M, Pisanello F.
Opt Express
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Ray tracing models for estimating light collection properties of microstructured tapered optical fibers for optical neural interfaces.
Authors: Authors: Maglie E, Pisanello M, Pisano F, Balena A, Bianco M, Spagnolo B, Sileo L, Sabatini BL, De Vittorio M, Pisanello F.
Opt Lett
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Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region-specific manner.
Authors: Authors: Granger AJ, Wang W, Robertson K, El-Rifai M, Zanello AF, Bistrong K, Saunders A, Chow BW, Nuñez V, Turrero García M, Harwell CC, Gu C, Sabatini BL.
Elife
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Caveolae in CNS arterioles mediate neurovascular coupling.
Authors: Authors: Chow BW, Nuñez V, Kaplan L, Granger AJ, Bistrong K, Zucker HL, Kumar P, Sabatini BL, Gu C.
Nature
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Anatomical and single-cell transcriptional profiling of the murine habenular complex.
Authors: Authors: Wallace ML, Huang KW, Hochbaum D, Hyun M, Radeljic G, Sabatini BL.
Elife
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