Bernardo Sabatini
Bernardo Sabatini, M.D., Ph.D.
Alice and Rodman W. Moorhead III Professor of Neurobiology

The main focus of my research laboratory is to understand the development and regulation of synapses in the brain and the relationship of these processes to behavior and disease.  Our studies include analysis of:

  1. The biophysical processes that control the function of individual synapses
  2. The mechanisms of regulation of synapses and neurons by neuromodulators such as dopamine, acetylcholine, and peptides
  3. The relationship between synaptic plasticity and behavior
  4. The role of perturbed synapse function in human neuropsychiatric diseases such as autism, Parkinson’s and Alzheimer’s

Our studies are performed in the mammalian brain and we focus on the analysis of hippocampus, cortex, and basal ganglia.  Recently, the analysis of the basal ganglia has become a major focus of the laboratory and we hope to perform a comprehensive analysis of the questions above in this brain structure.  Lastly, as necessary for our studies, we develop novel optical, electrophysiological, and behavioral approaches to carry out the proposed work. Greater detail and a complete list of publications can be found at our laboratory web site.

"Recently, the analysis of the basal ganglia has become a major focus of the laboratory and we hope to perform a comprehensive analysis of the questions above in this brain structure."

Publications View
Abnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B-/- Mice.
Authors: Authors: Peixoto RT, Chantranupong L, Hakim R, Levasseur J, Wang W, Merchant T, Gorman K, Budnik B, Sabatini BL.
Cell Rep
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Depth-resolved fiber photometry with a single tapered optical fiber implant.
Authors: Authors: Pisano F, Pisanello M, Lee SJ, Lee J, Maglie E, Balena A, Sileo L, Spagnolo B, Bianco M, Hyun M, De Vittorio M, Sabatini BL, Pisanello F.
Nat Methods
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Population imaging of neural activity in awake behaving mice.
Authors: Authors: Piatkevich KD, Bensussen S, Tseng HA, Shroff SN, Lopez-Huerta VG, Park D, Jung EE, Shemesh OA, Straub C, Gritton HJ, Romano MF, Costa E, Sabatini BL, Fu Z, Boyden ES, Han X.
Nature
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Molecular and anatomical organization of the dorsal raphe nucleus.
Authors: Authors: Huang KW, Ochandarena NE, Philson AC, Hyun M, Birnbaum JE, Cicconet M, Sabatini BL.
Elife
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In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function.
Authors: Authors: Tuesta LM, Djekidel MN, Chen R, Lu F, Wang W, Sabatini BL, Zhang Y.
Nat Commun
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Focused ion beam nanomachining of tapered optical fibers for patterned light delivery.
Authors: Authors: Pisano F, Pisanello M, Sileo L, Qualtieri A, Sabatini BL, De Vittorio M, Pisanello F.
Microelectron Eng
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Distinct Cortical-Thalamic-Striatal Circuits through the Parafascicular Nucleus.
Authors: Authors: Mandelbaum G, Taranda J, Haynes TM, Hochbaum DR, Huang KW, Hyun M, Umadevi Venkataraju K, Straub C, Wang W, Robertson K, Osten P, Sabatini BL.
Neuron
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Monitoring Behaviorally Induced Biochemical Changes Using Fluorescence Lifetime Photometry.
Authors: Authors: Lee SJ, Chen Y, Lodder B, Sabatini BL.
Front Neurosci
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The Three-Dimensional Signal Collection Field for Fiber Photometry in Brain Tissue.
Authors: Authors: Pisanello M, Pisano F, Hyun M, Maglie E, Balena A, De Vittorio M, Sabatini BL, Pisanello F.
Front Neurosci
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Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships.
Authors: Authors: Zhang P, Lu H, Peixoto RT, Pines MK, Ge Y, Oku S, Siddiqui TJ, Xie Y, Wu W, Archer-Hartmann S, Yoshida K, Tanaka KF, Aricescu AR, Azadi P, Gordon MD, Sabatini BL, Wong ROL, Craig AM.
Cell
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