Bernardo Sabatini
Bernardo Sabatini, MD, PhD
Alice and Rodman W. Moorhead III Professor of Neurobiology

The main focus of my research laboratory is to understand the development and regulation of synapses in the brain and the relationship of these processes to behavior and disease.  Our studies include analysis of:

  1. The biophysical processes that control the function of individual synapses
  2. The mechanisms of regulation of synapses and neurons by neuromodulators such as dopamine, acetylcholine, and peptides
  3. The relationship between synaptic plasticity and behavior
  4. The role of perturbed synapse function in human neuropsychiatric diseases such as autism, Parkinson’s and Alzheimer’s

Our studies are performed in the mammalian brain and we focus on the analysis of hippocampus, cortex, and basal ganglia.  Recently, the analysis of the basal ganglia has become a major focus of the laboratory and we hope to perform a comprehensive analysis of the questions above in this brain structure.  Lastly, as necessary for our studies, we develop novel optical, electrophysiological, and behavioral approaches to carry out the proposed work. Greater detail and a complete list of publications can be found at our laboratory website.


"Recently, the analysis of the basal ganglia has become a major focus of the laboratory and we hope to perform a comprehensive analysis of the questions above in this brain structure."

Publications View
A response to claims of emergent intelligence and sentience in a dish.
Authors: Authors: Balci F, Ben Hamed S, Boraud T, Bouret S, Brochier T, Brun C, Cohen JY, Coutureau E, Deffains M, Doyère V, Gregoriou GG, Heimel JA, Kilavik BE, Lee D, Leuthardt EC, Mainen ZF, Mathis M, Monosov IE, Naudé J, Orsborn AL, Padoa-Schioppa C, Procyk E, Sabatini B, Sallet J, Sandi C, Schall JD, Soltani A, Svoboda K, Wilson CRE, Zimmermann J.
View full abstract on Pubmed
A NPAS4-NuA4 complex couples synaptic activity to DNA repair.
Authors: Authors: Pollina EA, Gilliam DT, Landau AT, Lin C, Pajarillo N, Davis CP, Harmin DA, Yap EL, Vogel IR, Griffith EC, Nagy MA, Ling E, Duffy EE, Sabatini BL, Weitz CJ, Greenberg ME.
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Neuronal-Activity Dependent Mechanisms of Small Cell Lung Cancer Progression.
Authors: Authors: Savchuk S, Gentry K, Wang W, Carleton E, Yalçin B, Liu Y, Pavarino EC, LaBelle J, Toland AM, Woo PJ, Qu F, Filbin MG, Krasnow MA, Sabatini BL, Sage J, Monje M, Venkatesh HS.
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Spontaneous behaviour is structured by reinforcement without explicit reward.
Authors: Authors: Markowitz JE, Gillis WF, Jay M, Wood J, Harris RW, Cieszkowski R, Scott R, Brann D, Koveal D, Kula T, Weinreb C, Osman MAM, Pinto SR, Uchida N, Linderman SW, Sabatini BL, Datta SR.
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Mice exhibit stochastic and efficient action switching during probabilistic decision making.
Authors: Authors: Beron CC, Neufeld SQ, Linderman SW, Sabatini BL.
Proc Natl Acad Sci U S A
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Dendritic branch structure compartmentalizes voltage-dependent calcium influx in cortical layer 2/3 pyramidal cells.
Authors: Authors: Landau AT, Park P, Wong-Campos JD, Tian H, Cohen AE, Sabatini BL.
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Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical synapse development.
Authors: Authors: Xie Y, Kuan AT, Wang W, Herbert ZT, Mosto O, Olukoya O, Adam M, Vu S, Kim M, Tran D, Gómez N, Charpentier C, Sorour I, Lacey TE, Tolstorukov MY, Sabatini BL, Lee WA, Harwell CC.
Cell Rep
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Orthogonalization of far-field detection in tapered optical fibers for depth-selective fiber photometry in brain tissue.
Authors: Authors: Bianco M, Pisanello M, Balena A, Montinaro C, Pisano F, Spagnolo B, Sabatini BL, De Vittorio M, Pisanello F.
APL Photonics
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Co-packaging of opposing neurotransmitters in individual synaptic vesicles in the central nervous system.
Authors: Authors: Kim S, Wallace ML, El-Rifai M, Knudsen AR, Sabatini BL.
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Analytical approaches to examine gamma-aminobutyric acid and glutamate vesicular co-packaging.
Authors: Authors: Kim S, Sabatini BL.
Front Synaptic Neurosci
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