Portrait of a woman with shoulder-length wavy brown hair, wearing a dark blue top, against a softly blurred indoor background.

Lisa Goodrich, Ph.D.

Professor of Neurobiology, Harvard Medical School
Vice Chair of Neurobiology, Harvard Medical School

Lisa Goodrich, PhD – People Feature

Professor of Neurobiology and Department Vice Chair in the Department of Neurobiology at Harvard Medical School.

If you prefer, you can view the visual layout directly on Canva by Neuro Coordinator.

Contact

Email: lisa_goodrich@hms.harvard.edu

Goodrich Lab website: goodrich.med.harvard.edu

The Goal

The Goodrich Lab studies how hearing circuits form and function, and what leads to their deterioration.

The Impact

Studying how the brain and ear work together to produce our sense of hearing offers insight into a key sensory system that people and animals use to navigate the world.

Hearing can be impaired by genetic mutations, infection, or exposure to excessively loud sounds. Deciphering the cellular and molecular mechanisms underlying the formation and function of auditory circuits may lead to improved protection of hearing and treatments for hearing loss.

This work has the potential to help people of all ages more fully enjoy the sounds that enrich our lives.

A Closer Look

Harvard Medicine Magazine — Spring 2020: 5 Questions with a Neurobiologist: A Conversation with Lisa Goodrich

Lisa reflects on the rewards and challenges of life as a researcher and offers advice for others interested in pursuing scientific research. She discusses the molecular origins of sensory circuits, the rewards of scientific discovery, and the importance of flexibility in research and career paths.

Harvard Medical School News — November 2011: Bioengineering for Hearing, Sight and Mobility

Dr. Goodrich presented her research at the inaugural Bertarelli Neuroengineering Symposium in Lausanne, Switzerland. Support from the Bertarelli Foundation funded a project in her lab with the potential to help people whose lives are affected by hearing loss.

The featured research focuses on understanding auditory hair cells and developing approaches that could support improved treatments for hearing loss.

Publications View
Netrin-1 Confines Rhombic Lip-Derived Neurons to the CNS.
Authors: Authors: Yung AR, Druckenbrod NR, Cloutier JF, Wu Z, Tessier-Lavigne M, Goodrich LV.
Cell Rep
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Distinct functions for netrin 1 in chicken and murine semicircular canal morphogenesis.
Authors: Authors: Nishitani AM, Ohta S, Yung AR, Del Rio T, Gordon MI, Abraira VE, Avilés EC, Schoenwolf GC, Fekete DM, Goodrich LV.
Development
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Configuring a robust nervous system with Fat cadherins.
Authors: Authors: Avilés EC, Goodrich LV.
Semin Cell Dev Biol
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Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord.
Authors: Authors: Junge HJ, Yung AR, Goodrich LV, Chen Z.
Neural Dev
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Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet ß-Cells.
Authors: Authors: Banerjee RR, Cyphert HA, Walker EM, Chakravarthy H, Peiris H, Gu X, Liu Y, Conrad E, Goodrich L, Stein RW, Kim SK.
Diabetes
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Fat3 and Ena/VASP proteins influence the emergence of asymmetric cell morphology in the developing retina.
Authors: Authors: Krol A, Henle SJ, Goodrich LV.
Development
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The MAFB transcription factor impacts islet a-cell function in rodents and represents a unique signature of primate islet ß-cells.
Authors: Authors: Conrad E, Dai C, Spaeth J, Guo M, Cyphert HA, Scoville D, Carroll J, Yu WM, Goodrich LV, Harlan DM, Grove KL, Roberts CT, Powers AC, Gu G, Stein R.
Am J Physiol Endocrinol Metab
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Sequential Retraction Segregates SGN Processes during Target Selection in the Cochlea.
Authors: Authors: Druckenbrod NR, Goodrich LV.
J Neurosci
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Phenotypic analysis of mice completely lacking netrin 1.
Authors: Authors: Yung AR, Nishitani AM, Goodrich LV.
Development
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Mutation of Npr2 leads to blurred tonotopic organization of central auditory circuits in mice.
Authors: Authors: Lu CC, Cao XJ, Wright S, Ma L, Oertel D, Goodrich LV.
PLoS Genet
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