Portrait of a woman with shoulder-length wavy brown hair, wearing a dark blue top, against a softly blurred indoor background.

Lisa Goodrich, Ph.D.

Professor of Neurobiology, Harvard Medical School
Vice Chair of Neurobiology, Harvard Medical School

Lisa Goodrich, PhD – People Feature

Professor of Neurobiology and Department Vice Chair in the Department of Neurobiology at Harvard Medical School.

If you prefer, you can view the visual layout directly on Canva by Neuro Coordinator.

Contact

Email: lisa_goodrich@hms.harvard.edu

Goodrich Lab website: goodrich.med.harvard.edu

The Goal

The Goodrich Lab studies how hearing circuits form and function, and what leads to their deterioration.

The Impact

Studying how the brain and ear work together to produce our sense of hearing offers insight into a key sensory system that people and animals use to navigate the world.

Hearing can be impaired by genetic mutations, infection, or exposure to excessively loud sounds. Deciphering the cellular and molecular mechanisms underlying the formation and function of auditory circuits may lead to improved protection of hearing and treatments for hearing loss.

This work has the potential to help people of all ages more fully enjoy the sounds that enrich our lives.

A Closer Look

Harvard Medicine Magazine — Spring 2020: 5 Questions with a Neurobiologist: A Conversation with Lisa Goodrich

Lisa reflects on the rewards and challenges of life as a researcher and offers advice for others interested in pursuing scientific research. She discusses the molecular origins of sensory circuits, the rewards of scientific discovery, and the importance of flexibility in research and career paths.

Harvard Medical School News — November 2011: Bioengineering for Hearing, Sight and Mobility

Dr. Goodrich presented her research at the inaugural Bertarelli Neuroengineering Symposium in Lausanne, Switzerland. Support from the Bertarelli Foundation funded a project in her lab with the potential to help people whose lives are affected by hearing loss.

The featured research focuses on understanding auditory hair cells and developing approaches that could support improved treatments for hearing loss.

Publications View
Morphological and physiological development of auditory synapses.
Authors: Authors: Yu WM, Goodrich LV.
Hear Res
View full abstract on Pubmed
How to survive a nerve-wracking journey.
Authors: Authors: Yung A, Goodrich LV.
Elife
View full abstract on Pubmed
A Gata3-Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing.
Authors: Authors: Yu WM, Appler JM, Kim YH, Nishitani AM, Holt JR, Goodrich LV.
Elife
View full abstract on Pubmed
Gata3 is a critical regulator of cochlear wiring.
Authors: Authors: Appler JM, Lu CC, Druckenbrod NR, Yu WM, Koundakjian EJ, Goodrich LV.
J Neurosci
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In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear.
Authors: Authors: Del Rio T, Nishitani AM, Yu WM, Goodrich LV.
PLoS Genet
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Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity.
Authors: Authors: Saburi S, Hester I, Goodrich L, McNeill H.
Development
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Comparison of phenotypes between different vangl2 mutants demonstrates dominant effects of the Looptail mutation during hair cell development.
Authors: Authors: Yin H, Copley CO, Goodrich LV, Deans MR.
PLoS One
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Mutation of Rubie, a novel long non-coding RNA located upstream of Bmp4, causes vestibular malformation in mice.
Authors: Authors: Roberts KA, Abraira VE, Tucker AF, Goodrich LV, Andrews NC.
PLoS One
View full abstract on Pubmed
Control of neuronal morphology by the atypical cadherin Fat3.
Authors: Authors: Deans MR, Krol A, Abraira VE, Copley CO, Tucker AF, Goodrich LV.
Neuron
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Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly.
Authors: Authors: Lu CC, Appler JM, Houseman EA, Goodrich LV.
J Neurosci
View full abstract on Pubmed