Portrait of a woman with shoulder-length wavy brown hair, wearing a dark blue top, against a softly blurred indoor background.

Lisa Goodrich, Ph.D.

Professor of Neurobiology, Harvard Medical School
Vice Chair of Neurobiology, Harvard Medical School

Lisa Goodrich, PhD – People Feature

Professor of Neurobiology and Department Vice Chair in the Department of Neurobiology at Harvard Medical School.

If you prefer, you can view the visual layout directly on Canva by Neuro Coordinator.

Contact

Email: lisa_goodrich@hms.harvard.edu

Goodrich Lab website: goodrich.med.harvard.edu

The Goal

The Goodrich Lab studies how hearing circuits form and function, and what leads to their deterioration.

The Impact

Studying how the brain and ear work together to produce our sense of hearing offers insight into a key sensory system that people and animals use to navigate the world.

Hearing can be impaired by genetic mutations, infection, or exposure to excessively loud sounds. Deciphering the cellular and molecular mechanisms underlying the formation and function of auditory circuits may lead to improved protection of hearing and treatments for hearing loss.

This work has the potential to help people of all ages more fully enjoy the sounds that enrich our lives.

A Closer Look

Harvard Medicine Magazine — Spring 2020: 5 Questions with a Neurobiologist: A Conversation with Lisa Goodrich

Lisa reflects on the rewards and challenges of life as a researcher and offers advice for others interested in pursuing scientific research. She discusses the molecular origins of sensory circuits, the rewards of scientific discovery, and the importance of flexibility in research and career paths.

Harvard Medical School News — November 2011: Bioengineering for Hearing, Sight and Mobility

Dr. Goodrich presented her research at the inaugural Bertarelli Neuroengineering Symposium in Lausanne, Switzerland. Support from the Bertarelli Foundation funded a project in her lab with the potential to help people whose lives are affected by hearing loss.

The featured research focuses on understanding auditory hair cells and developing approaches that could support improved treatments for hearing loss.

Publications View
Runx1 controls auditory sensory neuron diversity in mice.
Authors: Authors: Shrestha BR, Wu L, Goodrich LV.
Dev Cell
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Fat3 acts through independent cytoskeletal effectors to coordinate asymmetric cell behaviors during polarized circuit assembly.
Authors: Authors: Avilés EC, Krol A, Henle SJ, Burroughs-Garcia J, Deans MR, Goodrich LV.
Cell Rep
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Diversity of developing peripheral glia revealed by single-cell RNA sequencing.
Authors: Authors: Tasdemir-Yilmaz OE, Druckenbrod NR, Olukoya OO, Dong W, Yung AR, Bastille I, Pazyra-Murphy MF, Sitko AA, Hale EB, Vigneau S, Gimelbrant AA, Kharchenko PV, Goodrich LV, Segal RA.
Dev Cell
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Making sense of neural development by comparing wiring strategies for seeing and hearing.
Authors: Authors: Sitko AA, Goodrich LV.
Science
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Sex-specific role for dopamine receptor D2 in dorsal raphe serotonergic neuron modulation of defensive acoustic startle and dominance behavior.
Authors: Authors: Lyon KA, Rood BD, Wu L, Senft RA, Goodrich LV, Dymecki SM.
eNeuro
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Neuronal processes and glial precursors form a scaffold for wiring the developing mouse cochlea.
Authors: Authors: Druckenbrod NR, Hale EB, Olukoya OO, Shatzer WE, Goodrich LV.
Nat Commun
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Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential mediator of epithelial fusion.
Authors: Authors: Hardy H, Prendergast JG, Patel A, Dutta S, Trejo-Reveles V, Kroeger H, Yung AR, Goodrich LV, Brooks B, Sowden JC, Rainger J.
Elife
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Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function.
Authors: Authors: Pai EL, Vogt D, Clemente-Perez A, McKinsey GL, Cho FS, Hu JS, Wimer M, Paul A, Fazel Darbandi S, Pla R, Nowakowski TJ, Goodrich LV, Paz JT, Rubenstein JLR.
Cell Rep
View full abstract on Pubmed
Talking back: Development of the olivocochlear efferent system.
Authors: Authors: Frank MM, Goodrich LV.
Wiley Interdiscip Rev Dev Biol
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Sensory Neuron Diversity in the Inner Ear Is Shaped by Activity.
Authors: Authors: Shrestha BR, Chia C, Wu L, Kujawa SG, Liberman MC, Goodrich LV.
Cell
View full abstract on Pubmed