Rosalind Segal, M.D., Ph.D.
Professor of Neurobiology, Dana-Farber Cancer Institute
Dean for Graduate Education, Harvard Medical School
Intercellular Communication
Our research focuses on intercellular communication: how growth factor signaling pathways regulate brain development, and how these pathways contribute to abnormal proliferation, migration and survival in brain tumors and in other neurologic disorders.
Publications View
Proteoglycan interactions with Sonic Hedgehog are selectively required for mitogenic responses
Authors: Authors: Chan JA, S Balasubramanian, RM Witt, KJ Nazemi, YJ Choi, CA Olson, M Thompson, RA Segal
Nature Neuroscience
Nature Neuroscience
Preparation and maintenance of dorsal root ganglia neurons in compartmented cultures.
A neuron-specific cytoplasmic dynein isoform preferentially transports TrkB signaling endosomes.
Authors: Authors: Ha J, Lo KW, Myers KR, Carr TM, Humsi MK, Rasoul BA, Segal RA, Pfister KK.
J Cell Biol
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J Cell Biol
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Action in the axon: generation and transport of signaling endosomes.
Authors: Authors: Cosker KE, Courchesne SL, Segal RA.
Curr Opin Neurobiol
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Curr Opin Neurobiol
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Polarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursors.
Authors: Authors: Zhou P, Porcionatto M, Pilapil M, Chen Y, Choi Y, Tolias KF, Bikoff JB, Hong EJ, Greenberg ME, Segal RA.
Neuron
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Neuron
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CXCR4 inhibition synergizes with cytotoxic chemotherapy in gliomas.
Authors: Authors: Redjal N, Chan JA, Segal RA, Kung AL.
Clin Cancer Res
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Clin Cancer Res
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Phase II study of neoadjuvant docetaxel and androgen suppression (AS) plus radiation therapy (RT) for high-risk localized prostate cancer (HRLCaP).
Authors: Authors: McKenzie MR, Chi KN, Neville A, Ellard S, Baerg B, Ruether D, Winquist E, Segal R, Lukka H.
J Clin Oncol
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J Clin Oncol
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Changing demographics of locally advanced breast cancer: Data from a regional cancer centre.
Authors: Authors: Segal R, Dent SF, Verma S, Canil CM, Azzi J, Vandermeer L, Spaans J.
J Clin Oncol
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J Clin Oncol
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Migration from a mitogenic niche promotes cell-cycle exit.
Subtracting the Math: prominin-positive cerebellar stem cells in white matter.