Rosalind Segal

Rosalind Segal, M.D., Ph.D.

Professor of Neurobiology, Dana-Farber Cancer Institute
Dean for Graduate Education, Harvard Medical School
617-632-4737
Segal Lab Website

Intercellular Communication

Our research focuses on intercellular communication: how growth factor signaling pathways regulate brain development, and how these pathways contribute to abnormal proliferation, migration and survival in brain tumors and in other neurologic disorders.

Publications View
P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp.
Authors: Authors: Wang KC, Kim JA, Sivasankaran R, Segal R, He Z.
Nature
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Medulloblastomas and primitive neuroectodermal tumors rarely contain polyomavirus DNA sequences.
Authors: Authors: Kim JY, Koralnik IJ, LeFave M, Segal RA, Pfister LA, Pomeroy SL.
Neuro Oncol
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High-resolution imaging demonstrates dynein-based vesicular transport of activated Trk receptors.
Authors: Authors: Bhattacharyya A, Watson FL, Pomeroy SL, Zhang YZ, Stiles CD, Segal RA.
J Neurobiol
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Retrograde neurotrophin signaling: Trk-ing along the axon.
Authors: Authors: Ginty DD, Segal RA.
Curr Opin Neurobiol
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Cerebellar proteoglycans regulate sonic hedgehog responses during development.
Authors: Authors: Rubin JB, Choi Y, Segal RA.
Development
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Location, location, location: a spatial view of neurotrophin signal transduction.
Authors: Authors: Heerssen HM, Segal RA.
Trends Neurosci
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BDNF stimulates migration of cerebellar granule cells.
Authors: Authors: Borghesani PR, Peyrin JM, Klein R, Rubin J, Carter AR, Schwartz PM, Luster A, Corfas G, Segal RA.
Development
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Brain-derived neurotrophic factor modulates cerebellar plasticity and synaptic ultrastructure.
Authors: Authors: Carter AR, Chen C, Schwartz PM, Segal RA.
J Neurosci
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Neurotrophins use the Erk5 pathway to mediate a retrograde survival response.
Authors: Authors: Watson FL, Heerssen HM, Bhattacharyya A, Klesse L, Lin MZ, Segal RA.
Nat Neurosci
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Changing patterns of presentations of patients with HIV-related disease at a tertiary referral centre and its implications for physician training.
Authors: Authors: Segal R, Poznansky MC, Connors L, Sands K, Barlam T.
Int J STD AIDS
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