Rosalind Segal, M.D., Ph.D.
Professor of Neurobiology, Dana-Farber Cancer Institute
Dean for Graduate Education, Harvard Medical School
Intercellular Communication
Our research focuses on intercellular communication: how growth factor signaling pathways regulate brain development, and how these pathways contribute to abnormal proliferation, migration and survival in brain tumors and in other neurologic disorders.
Publications View
Retrograde neurotrophin signaling: Trk-ing along the axon.
Cerebellar proteoglycans regulate sonic hedgehog responses during development.
BDNF stimulates migration of cerebellar granule cells.
Authors: Authors: Borghesani PR, Peyrin JM, Klein R, Rubin J, Carter AR, Schwartz PM, Luster A, Corfas G, Segal RA.
Development
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Development
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Location, location, location: a spatial view of neurotrophin signal transduction.
Brain-derived neurotrophic factor modulates cerebellar plasticity and synaptic ultrastructure.
Neurotrophins use the Erk5 pathway to mediate a retrograde survival response.
Authors: Authors: Watson FL, Heerssen HM, Bhattacharyya A, Klesse L, Lin MZ, Segal RA.
Nat Neurosci
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Nat Neurosci
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Changing patterns of presentations of patients with HIV-related disease at a tertiary referral centre and its implications for physician training.
Authors: Authors: Segal R, Poznansky MC, Connors L, Sands K, Barlam T.
Int J STD AIDS
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Int J STD AIDS
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SDF-1 alpha induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells.
Authors: Authors: Klein RS, Rubin JB, Gibson HD, DeHaan EN, Alvarez-Hernandez X, Segal RA, Luster AD.
Development
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Development
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Neurotrophins: which way did they go?
Generation and utilization of phosphorylation state-specific antibodies to investigate signaling pathways.