Rosalind Segal

Rosalind Segal, M.D., Ph.D.

Professor of Neurobiology, Dana-Farber Cancer Institute
Dean for Graduate Education, Harvard Medical School
617-632-4737
Segal Lab Website

Intercellular Communication

Our research focuses on intercellular communication: how growth factor signaling pathways regulate brain development, and how these pathways contribute to abnormal proliferation, migration and survival in brain tumors and in other neurologic disorders.

Publications View
Dynein motors transport activated Trks to promote survival of target-dependent neurons.
Authors: Authors: Heerssen HM, Pazyra MF, Segal RA.
Nat Neurosci
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A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.
Authors: Authors: Rubin JB, Kung AL, Klein RS, Chan JA, Sun Y, Schmidt K, Kieran MW, Luster AD, Segal RA.
Proc Natl Acad Sci U S A
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Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice.
Authors: Authors: Kim JY, Nelson AL, Algon SA, Graves O, Sturla LM, Goumnerova LC, Rowitch DH, Segal RA, Pomeroy SL.
Dev Biol
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Modulation of autoreactive responses of peripheral blood lymphocytes of patients with systemic lupus erythematosus by peptides based on human and murine anti-DNA autoantibodies.
Authors: Authors: Sthoeger ZM, Dayan M, Tcherniack A, Green L, Toledo S, Segal R, Elkayam O, Mozes E.
Clin Exp Immunol
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Selectivity in neurotrophin signaling: theme and variations.
Authors: Authors: Segal RA.
Annu Rev Neurosci
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Growth, survival and migration: the Trk to cancer.
Authors: Authors: Rubin JB, Segal RA.
Cancer Treat Res
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Regional expression of p75NTR contributes to neurotrophin regulation of cerebellar patterning.
Authors: Authors: Carter AR, Berry EM, Segal RA.
Mol Cell Neurosci
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P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp.
Authors: Authors: Wang KC, Kim JA, Sivasankaran R, Segal R, He Z.
Nature
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Medulloblastomas and primitive neuroectodermal tumors rarely contain polyomavirus DNA sequences.
Authors: Authors: Kim JY, Koralnik IJ, LeFave M, Segal RA, Pfister LA, Pomeroy SL.
Neuro Oncol
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High-resolution imaging demonstrates dynein-based vesicular transport of activated Trk receptors.
Authors: Authors: Bhattacharyya A, Watson FL, Pomeroy SL, Zhang YZ, Stiles CD, Segal RA.
J Neurobiol
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