Rosalind Segal

Rosalind Segal, M.D., Ph.D.

Professor of Neurobiology, Dana-Farber Cancer Institute
Dean for Graduate Education, Harvard Medical School
617-632-4737
Segal Lab Website

Intercellular Communication

Our research focuses on intercellular communication: how growth factor signaling pathways regulate brain development, and how these pathways contribute to abnormal proliferation, migration and survival in brain tumors and in other neurologic disorders.

Publications View
Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
Authors: Authors: Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson RT, Springer TA.
Proc Natl Acad Sci U S A
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Cerebellar pathology in BDNF -/- mice: the classic view of neurotrophins is changing.
Authors: Authors: Schwartz PM, Levy RL, Borghesani PR, Segal RA.
Mol Psychiatry
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Neurotrophins in cerebellar granule cell development and medulloblastoma.
Authors: Authors: Pomeroy SL, Sutton ME, Goumnerova LC, Segal RA.
J Neurooncol
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Trk receptors function as rapid retrograde signal carriers in the adult nervous system.
Authors: Authors: Bhattacharyya A, Watson FL, Bradlee TA, Pomeroy SL, Stiles CD, Segal RA.
J Neurosci
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Abnormal cerebellar development and foliation in BDNF-/- mice reveals a role for neurotrophins in CNS patterning.
Authors: Authors: Schwartz PM, Borghesani PR, Levy RL, Pomeroy SL, Segal RA.
Neuron
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Blockade of endogenous ligands of trkB inhibits formation of ocular dominance columns.
Authors: Authors: Cabelli RJ, Shelton DL, Segal RA, Shatz CJ.
Neuron
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Cytokine manipulation by methotrexate treatment in murine experimental systemic lupus erythematosus.
Authors: Authors: Dayan M, Segal R, Mozes E.
J Rheumatol
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Effect of aging on cytokine production in normal and experimental systemic lupus erythematosus afflicted mice.
Authors: Authors: Segal R, Dayan M, Globerson A, Habut B, Shearer GM, Mozes E.
Mech Ageing Dev
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Kinetics of cytokine production in experimental systemic lupus erythematosus: involvement of T helper cell 1/T helper cell 2-type cytokines in disease.
Authors: Authors: Segal R, Bermas BL, Dayan M, Kalush F, Shearer GM, Mozes E.
J Immunol
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Regulation of neuronal survival by the serine-threonine protein kinase Akt.
Authors: Authors: Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME.
Science
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