Bruce Bean, PhD

Title: Robert Winthrop Professor of Neurobiology, Harvard Medical School.

The Aim

The Bean Lab studies the pharmacology of ion channels that govern the electrical activity of neurons. Neuronal activity is regulated by molecular gates in the cell membrane called ion channels.

The Impact

Different types of neurons express different combinations of ion channels, which is why they fire differently and serve different functions. The Bean Lab uses pharmacology to study how ion channels differentially regulate electrical activity in particular kinds of neurons, both characterizing existing ion channel–targeted drugs and developing new ones. This approach has contributed to the development of new compounds that target channels in pain‑sensing neurons without the side effects and risks associated with opioids. Ongoing projects aim to develop new drugs targeting chronic pain, epilepsy, and multiple sclerosis.

A Closer Look

Article: “This Will Have a Negative Effect on the Entire Drug‑Development Enterprise” , Harvard Medicine Magazine, July 2025. This perspective explains how Bruce Bean’s lab uses basic research on neuronal ion channels and hyperexcitability to identify new, safer drug targets for pain and epilepsy, positioning the lab as an early‑stage engine for future non‑opioid therapies.

Article: The Discovery Channel: Why do Harvard doctors remain undaunted by the demands of discovery? , Harvard Medicine Magazine, Spring 2011. This feature describes how Harvard is boosting drug discovery by supporting risky early‑stage projects and collaborations; Bruce Bean’s ion‑channel research is highlighted as an example of identifying new targets for pain and epilepsy treatments that industry can later develop into drugs.

Contact

Email: bruce_bean@hms.harvard.edu