Rosalind Segal

Rosalind Segal, M.D., Ph.D.

Professor of Neurobiology, Dana-Farber Cancer Institute
Dean for Graduate Education, Harvard Medical School
617-632-4737
Segal Lab Website

Intercellular Communication

Our research focuses on intercellular communication: how growth factor signaling pathways regulate brain development, and how these pathways contribute to abnormal proliferation, migration and survival in brain tumors and in other neurologic disorders.

Publications View
Uncomfortably numb: how Nav1.7 mediates paclitaxel-induced peripheral neuropathy.
Authors: Authors: Silagi ES, Segal RA.
Brain
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The Eya1 Phosphatase Mediates Shh-Driven Symmetric Cell Division of Cerebellar Granule Cell Precursors.
Authors: Authors: Merk DJ, Zhou P, Cohen SM, Pazyra-Murphy MF, Hwang GH, Rehm KJ, Alfaro J, Reid CM, Zhao X, Park E, Xu PX, Chan JA, Eck MJ, Nazemi KJ, Harwell CC, Segal RA.
Dev Neurosci
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Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival.
Authors: Authors: Fukuda Y, Pazyra-Murphy MF, Silagi ES, Tasdemir-Yilmaz OE, Li Y, Rose L, Yeoh ZC, Vangos NE, Geffken EA, Seo HS, Adelmant G, Bird GH, Walensky LD, Marto JA, Dhe-Paganon S, Segal RA.
J Cell Biol
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Understanding The Epigenetic Landscape and Cellular Architecture of Childhood Brain Tumors.
Authors: Authors: Veiga Cruzeiro GA, Rota C, Hack OA, Segal R, Filbin MG.
Neurochem Int
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Recognizing Team Science Contributions in Academic Hiring, Promotion, and Tenure.
Authors: Authors: Cline H, Coolen L, de Vries S, Hyman S, Segal R, Steward O.
J Neurosci
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An Architect of the Hindbrain: DDX3X Regulates Normal and Malignant Development.
Authors: Authors: Hwang GH, Segal RA.
Dev Cell
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Roadmap for the Emerging Field of Cancer Neuroscience.
Authors: Authors: Monje M, Borniger JC, D'Silva NJ, Deneen B, Dirks PB, Fattahi F, Frenette PS, Garzia L, Gutmann DH, Hanahan D, Hervey-Jumper SL, Hondermarck H, Hurov JB, Kepecs A, Knox SM, Lloyd AC, Magnon C, Saloman JL, Segal RA, Sloan EK, Sun X, Taylor MD, Tracey KJ, Trotman LC, Tuveson DA, Wang TC, White RA, Winkler F.
Cell
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Pathogenesis of paclitaxel-induced peripheral neuropathy: A current review of in vitro and in vivo findings using rodent and human model systems.
Authors: Authors: Staff NP, Fehrenbacher JC, Caillaud M, Damaj MI, Segal RA, Rieger S.
Exp Neurol
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Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells.
Authors: Authors: Reitman ZJ, Paolella BR, Bergthold G, Pelton K, Becker S, Jones R, Sinai CE, Malkin H, Huang Y, Grimmet L, Herbert ZT, Sun Y, Weatherbee JL, Alberta JA, Daley JF, Rozenblatt-Rosen O, Condurat AL, Qian K, Khadka P, Segal RA, Haas-Kogan D, Filbin MG, Suva ML, Regev A, Stiles CD, Kieran MW, Goumnerova L, Ligon KL, Shalek AK, Bandopadhayay P, Beroukhim R.
Nat Commun
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A large-scale drug screen identifies selective inhibitors of class I HDACs as a potential therapeutic option for SHH medulloblastoma.
Authors: Authors: Pak E, MacKenzie EL, Zhao X, Pazyra-Murphy MF, Park PMC, Wu L, Shaw DL, Addleson EC, Cayer SS, Lopez BG, Agar NYR, Rubin LL, Qi J, Merk DJ, Segal RA.
Neuro Oncol
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