Rosalind Segal

Rosalind Segal, M.D., Ph.D.

Professor of Neurobiology, Dana-Farber Cancer Institute
Dean for Graduate Education, Harvard Medical School
617-632-4737
Segal Lab Website

Intercellular Communication

Our research focuses on intercellular communication: how growth factor signaling pathways regulate brain development, and how these pathways contribute to abnormal proliferation, migration and survival in brain tumors and in other neurologic disorders.

Publications View
Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27.
Authors: Authors: Arimura N, Kimura T, Nakamuta S, Taya S, Funahashi Y, Hattori A, Shimada A, Ménager C, Kawabata S, Fujii K, Iwamatsu A, Segal RA, Fukuda M, Kaibuchi K.
Dev Cell
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Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses.
Authors: Authors: Chan JA, Balasubramanian S, Witt RM, Nazemi KJ, Choi Y, Pazyra-Murphy MF, Walsh CO, Thompson M, Segal RA.
Nat Neurosci
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Olfactory behavioral testing in the adult mouse.
Authors: Authors: Witt RM, Galligan MM, Despinoy JR, Segal R.
J Vis Exp
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Proteoglycan interactions with Sonic Hedgehog are selectively required for mitogenic responses
Authors: Authors: Chan JA, S Balasubramanian, RM Witt, KJ Nazemi, YJ Choi, CA Olson, M Thompson, RA Segal
Nature Neuroscience
Preparation and maintenance of dorsal root ganglia neurons in compartmented cultures.
Authors: Authors: Pazyra-Murphy MF, Segal RA.
J Vis Exp
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A neuron-specific cytoplasmic dynein isoform preferentially transports TrkB signaling endosomes.
Authors: Authors: Ha J, Lo KW, Myers KR, Carr TM, Humsi MK, Rasoul BA, Segal RA, Pfister KK.
J Cell Biol
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Action in the axon: generation and transport of signaling endosomes.
Authors: Authors: Cosker KE, Courchesne SL, Segal RA.
Curr Opin Neurobiol
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Polarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursors.
Authors: Authors: Zhou P, Porcionatto M, Pilapil M, Chen Y, Choi Y, Tolias KF, Bikoff JB, Hong EJ, Greenberg ME, Segal RA.
Neuron
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CXCR4 inhibition synergizes with cytotoxic chemotherapy in gliomas.
Authors: Authors: Redjal N, Chan JA, Segal RA, Kung AL.
Clin Cancer Res
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Changing demographics of locally advanced breast cancer: Data from a regional cancer centre.
Authors: Authors: Segal R, Dent SF, Verma S, Canil CM, Azzi J, Vandermeer L, Spaans J.
J Clin Oncol
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