Rosalind Segal

Rosalind Segal, M.D., Ph.D.

Professor of Neurobiology, Dana-Farber Cancer Institute

Dean for Graduate Education, Harvard Medical School

617-632-4737

Segal Lab Website

Research
Publications

Intercellular Communication

Our research focuses on intercellular communication: how growth factor signaling pathways regulate brain development, and how these pathways contribute to abnormal proliferation, migration and survival in brain tumors and in other neurologic disorders.

Publications View

Can the referring surgeon enhance accrual of breast cancer patients to medical and radiation oncology trials? The ENHANCE study.

Authors: Authors: Arnaout A, Kuchuk I, Bouganim N, Pond G, Verma S, Segal R, Dent S, Gertler S, Song X, Kanji F, Clemons M.
Curr Oncol 2016-06-01
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The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability.

Authors: Authors: Cosker KE, Fenstermacher SJ, Pazyra-Murphy MF, Elliott HL, Segal RA.
Nat Neurosci 2016-05-01
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Lessons from a bridge generation.

Authors: Authors: Segal RA.
Science 2016-03-25
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How neuronal activity regulates glioma cell proliferation.

Authors: Authors: Filbin MG, Segal RA.
Neuro Oncol 2015-12-01
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A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies.

Authors: Authors: Chadwick EJ, Yang DP, Filbin MG, Mazzola E, Sun Y, Behar O, Pazyra-Murphy MF, Goumnerova L, Ligon KL, Stiles CD, Segal RA.
J Vis Exp 2015-11-07
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Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype.

Authors: Authors: Bergthold G, Bandopadhayay P, Hoshida Y, Ramkissoon S, Ramkissoon L, Rich B, Maire CL, Paolella BR, Schumacher SE, Tabak B, Ferrer-Luna R, Ozek M, Sav A, Santagata S, Wen PY, Goumnerova LC, Ligon AH, Stiles C, Segal R, Golub T, Grill J, Ligon KL, Chan JA, Kieran MW, Beroukhim R.
Neuro Oncol 2015-11-01
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Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons.

Authors: Authors: Balastik M, Zhou XZ, Alberich-Jorda M, Weissova R, Žiak J, Pazyra-Murphy MF, Cosker KE, Machonova O, Kozmikova I, Chen CH, Pastorino L, Asara JM, Cole A, Sutherland C, Segal RA, Lu KP.
Cell Rep 2015-10-27
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A Polyamine Twist on Hedgehog Signaling.

Authors: Authors: Zhao X, Segal RA.
Dev Cell 2015-10-12
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CD151-a3ß1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion.

Authors: Authors: Zhou P, Erfani S, Liu Z, Jia C, Chen Y, Xu B, Deng X, Alfáro JE, Chen L, Napier D, Lu M, Huang JA, Liu C, Thibault O, Segal R, Zhou BP, Kyprianou N, Horbinski C, Yang XH.
Oncotarget 2015-10-06
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RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors.

Authors: Authors: Zhao X, Ponomaryov T, Ornell KJ, Zhou P, Dabral SK, Pak E, Li W, Atwood SX, Whitson RJ, Chang AL, Li J, Oro AE, Chan JA, Kelleher JF, Segal RA.
Cancer Res 2015-09-01
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