Intercellular Communication
Our research focuses on intercellular communication: how growth factor signaling pathways regulate brain development, and how these pathways contribute to abnormal proliferation, migration and survival in brain tumors and in other neurologic disorders.
Publications View
Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons.
Authors: Authors: Balastik M, Zhou XZ, Alberich-Jorda M, Weissova R, Žiak J, Pazyra-Murphy MF, Cosker KE, Machonova O, Kozmikova I, Chen CH, Pastorino L, Asara JM, Cole A, Sutherland C, Segal RA, Lu KP.
Cell Rep
View full abstract on Pubmed
Cell Rep
View full abstract on Pubmed
A Polyamine Twist on Hedgehog Signaling.
CD151-a3ß1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion.
Authors: Authors: Zhou P, Erfani S, Liu Z, Jia C, Chen Y, Xu B, Deng X, Alfáro JE, Chen L, Napier D, Lu M, Huang JA, Liu C, Thibault O, Segal R, Zhou BP, Kyprianou N, Horbinski C, Yang XH.
Oncotarget
View full abstract on Pubmed
Oncotarget
View full abstract on Pubmed
RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors.
Authors: Authors: Zhao X, Ponomaryov T, Ornell KJ, Zhou P, Dabral SK, Pak E, Li W, Atwood SX, Whitson RJ, Chang AL, Li J, Oro AE, Chan JA, Kelleher JF, Segal RA.
Cancer Res
View full abstract on Pubmed
Cancer Res
View full abstract on Pubmed
The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis.
Authors: Authors: Eisner A, Pazyra-Murphy MF, Durresi E, Zhou P, Zhao X, Chadwick EC, Xu PX, Hillman RT, Scott MP, Greenberg ME, Segal RA.
Dev Cell
View full abstract on Pubmed
Dev Cell
View full abstract on Pubmed
Shh-proteoglycan interactions regulate maturation of olfactory glomerular circuitry.
Authors: Authors: Persson L, Witt RM, Galligan M, Greer PL, Eisner A, Pazyra-Murphy MF, Datta SR, Segal RA.
Dev Neurobiol
View full abstract on Pubmed
Dev Neurobiol
View full abstract on Pubmed
Preserve and protect: maintaining axons within functional circuits.
Pediatric low-grade gliomas: how modern biology reshapes the clinical field.
Authors: Authors: Bergthold G, Bandopadhayay P, Bi WL, Ramkissoon L, Stiles C, Segal RA, Beroukhim R, Ligon KL, Grill J, Kieran MW.
Biochim Biophys Acta
View full abstract on Pubmed
Biochim Biophys Acta
View full abstract on Pubmed
Neuronal signaling through endocytosis.
New progenitors NESTIN(g) in the EGL.