Rosalind Segal

Rosalind Segal, M.D., Ph.D.

Professor of Neurobiology, Dana-Farber Cancer Institute

Dean for Graduate Education, Harvard Medical School

617-632-4737

Segal Lab Website

Research
Publications

Intercellular Communication

Our research focuses on intercellular communication: how growth factor signaling pathways regulate brain development, and how these pathways contribute to abnormal proliferation, migration and survival in brain tumors and in other neurologic disorders.

Publications View

The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis.

Authors: Authors: Eisner A, Pazyra-Murphy MF, Durresi E, Zhou P, Zhao X, Chadwick EC, Xu PX, Hillman RT, Scott MP, Greenberg ME, Segal RA.
Dev Cell 2015-04-06
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Shh-proteoglycan interactions regulate maturation of olfactory glomerular circuitry.

Authors: Authors: Persson L, Witt RM, Galligan M, Greer PL, Eisner A, Pazyra-Murphy MF, Datta SR, Segal RA.
Dev Neurobiol 2014-12-01
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Preserve and protect: maintaining axons within functional circuits.

Authors: Authors: Pease SE, Segal RA.
Trends Neurosci 2014-10-01
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Pediatric low-grade gliomas: how modern biology reshapes the clinical field.

Authors: Authors: Bergthold G, Bandopadhayay P, Bi WL, Ramkissoon L, Stiles C, Segal RA, Beroukhim R, Ligon KL, Grill J, Kieran MW.
Biochim Biophys Acta 2014-04-01
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Neuronal signaling through endocytosis.

Authors: Authors: Cosker KE, Segal RA.
Cold Spring Harb Perspect Biol 2014-02-01
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New progenitors NESTIN(g) in the EGL.

Authors: Authors: Pak E, Segal RA, Stiles CD.
Nat Neurosci 2013-12-01
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Preference weights for chemotherapy side effects from the perspective of women with breast cancer.

Authors: Authors: Kuchuk I, Bouganim N, Beusterien K, Grinspan J, Vandermeer L, Gertler S, Dent SF, Song X, Segal R, Mazzarello S, Crawley F, Dranitsaris G, Clemons M.
Breast Cancer Res Treat 2013-11-01
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Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities.

Authors: Authors: Filbin MG, Dabral SK, Pazyra-Murphy MF, Ramkissoon S, Kung AL, Pak E, Chung J, Theisen MA, Sun Y, Franchetti Y, Sun Y, Shulman DS, Redjal N, Tabak B, Beroukhim R, Wang Q, Zhao J, Dorsch M, Buonamici S, Ligon KL, Kelleher JF, Segal RA.
Nat Med 2013-11-01
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Heparan sulfate proteoglycans containing a glypican 5 core and 2-O-sulfo-iduronic acid function as Sonic Hedgehog co-receptors to promote proliferation.

Authors: Authors: Witt RM, Hecht ML, Pazyra-Murphy MF, Cohen SM, Noti C, van Kuppevelt TH, Fuller M, Chan JA, Hopwood JJ, Seeberger PH, Segal RA.
J Biol Chem 2013-09-06
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Target-derived neurotrophins coordinate transcription and transport of bclw to prevent axonal degeneration.

Authors: Authors: Cosker KE, Pazyra-Murphy MF, Fenstermacher SJ, Segal RA.
J Neurosci 2013-03-20
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