Rosalind Segal

Rosalind Segal, M.D., Ph.D.

Professor of Neurobiology, Dana-Farber Cancer Institute
Dean for Graduate Education, Harvard Medical School
617-632-4737
Segal Lab Website

Intercellular Communication

Our research focuses on intercellular communication: how growth factor signaling pathways regulate brain development, and how these pathways contribute to abnormal proliferation, migration and survival in brain tumors and in other neurologic disorders.

Publications View
Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation.
Authors: Authors: Zhang Y, Moheban DB, Conway BR, Bhattacharyya A, Segal RA.
J Neurosci
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Immune response of SLE patients to peptides based on the complementarity determining regions of a pathogenic anti-DNA monoclonal antibody.
Authors: Authors: Dayan M, Segal R, Sthoeger Z, Waisman A, Brosh N, Elkayam O, Eilat E, Fridkin M, Mozes E.
J Clin Immunol
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Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice.
Authors: Authors: Borghesani PR, Alt FW, Bottaro A, Davidson L, Aksoy S, Rathbun GA, Roberts TM, Swat W, Segal RA, Gu Y.
Proc Natl Acad Sci U S A
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Effect of aging on cytokine production in normal and experimental systemic lupus erythematosus-afflicted mice.
Authors: Authors: Dayan M, Segal R, Globerson A, Habut B, Shearer GM, Mozes E.
Exp Gerontol
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Combination of epirubicin and cisplatin in hormone-refractory metastatic prostate cancer.
Authors: Authors: Huan SD, Stewart DJ, Aitken SE, Segal R, Yau JC.
Am J Clin Oncol
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Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex.
Authors: Authors: Watson FL, Heerssen HM, Moheban DB, Lin MZ, Sauvageot CM, Bhattacharyya A, Pomeroy SL, Segal RA.
J Neurosci
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TrkA glycosylation regulates receptor localization and activity.
Authors: Authors: Watson FL, Porcionatto MA, Bhattacharyya A, Stiles CD, Segal RA.
J Neurobiol
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Intermittent androgen suppression in the management of prostate cancer.
Authors: Authors: Crook JM, Szumacher E, Malone S, Huan S, Segal R.
Urology
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Activation of neurotrophin-3 receptor TrkC induces apoptosis in medulloblastomas.
Authors: Authors: Kim JY, Sutton ME, Lu DJ, Cho TA, Goumnerova LC, Goritchenko L, Kaufman JR, Lam KK, Billet AL, Tarbell NJ, Wu J, Allen JC, Stiles CD, Segal RA, Pomeroy SL.
Cancer Res
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Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
Authors: Authors: Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson RT, Springer TA.
Proc Natl Acad Sci U S A
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