Rosalind Segal, M.D., Ph.D.

Rosalind Segal, MD, PhD – Faculty Profile

Professor of Neurobiology at the Dana-Farber Cancer Institute and Dean for Graduate Education at Harvard Medical School.

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Contact

Email: roz_segal@hms.harvard.edu

Segal Lab website: segallab.dana-farber.org

The Aim

The Segal Lab studies neuronal signaling pathways in cancer and nerve cell responses to chemotherapy, aiming to develop better treatments for nervous system disorders and reduce a common side effect of chemotherapy: neuropathic pain.

The Impact

The Segal Lab is interested in extending our knowledge of neuronal signaling pathways to treat disorders of the nervous system. A particular area of interest is understanding how neurons contribute to cancers of the brain, and specifically how nerve cells respond to chemotherapies. This is especially important in cases where cancer treatments can cause damage to nerve cells, leading to neuropathic pain in patients.

The Segal Lab’s work aims to create more effective approaches to mitigate these side effects, as well as to better understand how signaling pathways in neurons can be leveraged to understand nervous system diseases.

A Closer Look

Dana-Farber Cancer Institute: Discovery Suggests Approach to Preventing Peripheral Neuropathy

This article describes research led by Rosalind Segal showing how a protein called Bcl-w helps protect nerve axons. The research suggests that restoring or mimicking Bcl-w may help prevent chemotherapy-induced peripheral neuropathy, which can cause numbness, tingling, and pain in the hands and feet.

Segal Lab research: Research at the Segal Lab

The Segal Lab researches how specific signaling pathways control brain tumor growth and neuron survival. This work aims to support the development of targeted therapies for brain cancers and treatments that prevent nerve degeneration.

Additional Profile Information

Rosalind Segal, MD, PhD, is a Professor of Neurobiology at the Dana-Farber Cancer Institute and Dean for Graduate Education at Harvard Medical School.