Flier

Jeffrey S. Flier, MD

Higginson Professor of Physiology and Medicine
Harvard University Distinguished Service Professor
Former Dean of the Faculty of Medicine (2007- 2016)
Publications View
Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet.
Authors: Authors: Douris N, Melman T, Pecherer JM, Pissios P, Flier JS, Cantley LC, Locasale JW, Maratos-Flier E.
Biochim Biophys Acta
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Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice.
Authors: Authors: Douris N, Stevanovic DM, Fisher FM, Cisu TI, Chee MJ, Nguyen NL, Zarebidaki E, Adams AC, Kharitonenkov A, Flier JS, Bartness TJ, Maratos-Flier E.
Endocrinology
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Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets.
Authors: Authors: Fisher FM, Chui PC, Nasser IA, Popov Y, Cunniff JC, Lundasen T, Kharitonenkov A, Schuppan D, Flier JS, Maratos-Flier E.
Gastroenterology
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Adipsin is an adipokine that improves ß cell function in diabetes.
Authors: Authors: Lo JC, Ljubicic S, Leibiger B, Kern M, Leibiger IB, Moede T, Kelly ME, Chatterjee Bhowmick D, Murano I, Cohen P, Banks AS, Khandekar MJ, Dietrich A, Flier JS, Cinti S, Blüher M, Danial NN, Berggren PO, Spiegelman BM.
Cell
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Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo.
Authors: Authors: Domouzoglou EM, Fisher FM, Astapova I, Fox EC, Kharitonenkov A, Flier JS, Hollenberg AN, Maratos-Flier E.
Endocrinology
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Creating a Nobel culture.
Authors: Authors: Flier JS.
Science
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a-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors.
Authors: Authors: Robins SC, Stewart I, McNay DE, Taylor V, Giachino C, Goetz M, Ninkovic J, Briancon N, Maratos-Flier E, Flier JS, Kokoeva MV, Placzek M.
Nat Commun
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Hormone resistance in diabetes and obesity: insulin, leptin, and FGF21.
Authors: Authors: Flier JS.
Yale J Biol Med
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FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis.
Authors: Authors: Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM.
Genes Dev
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Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice.
Authors: Authors: McNay DE, Briançon N, Kokoeva MV, Maratos-Flier E, Flier JS.
J Clin Invest
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