Portrait of a smiling man with white hair and round glasses, wearing a pink patterned shirt against a light-colored wall.

Gord Fishell, Ph.D.

Professor of Neurobiology, Harvard Medical School

Accessible description of graphic: One-page profile titled “Gord Fishell, Ph.D.” with the subtitle “Professor of Neurobiology, Harvard Medical School.” At the top right is a portrait photo of Gord Fishell. Under the title there are two circular buttons: one linking to his email address and one to his laboratory website. The email button links to gordon_fishell@hms.harvard.edu and the lab button links to fishelllab.hms.harvard.edu .

Under the heading “The Aim”, the text reads: “The Fishell Lab investigates how inhibitory interneurons, the brain's primary gating system of information flow, are generated and integrated into circuits during development.”

Under the heading “The Impact”, the text explains that brain function depends on a balance between excitation and inhibition, and that inhibitory interneurons are responsible for maintaining that balance. The Fishell Lab’s research reveals a remarkable diversity of interneuron subtypes, each with its own shape, connectivity, and function. Mapping the developmental origins of interneuron diversity is opening new avenues for therapeutic approaches to conditions such as autism and schizophrenia.

A section titled “A Closer Look” highlights two featured studies. The first is labeled “Nature – May 2026” and is illustrated with a multipanel figure. The caption explains that this paper discusses new research that pinpoints a specific set of brain cells in mice that rapidly detect danger and convert signals from memory and emotion centers into defensive actions such as freezing or escaping. You can read this article at the related Nature publication (external link) .

The second featured item is labeled “Harvard Medical School – December 2021”, with an illustration titled “The Brain’s Wiring Technicians.” The text explains that Gord Fishell’s team discovered a specialized subset of microglia—immune cells in the brain—that home in on and selectively “prune” inhibitory synapses via GABA receptors. This pruning helps balance excitation and inhibition in developing circuits and suggests new ways to fix miswired brain networks in disorders such as autism, ADHD, and schizophrenia. A related article can be accessed at the Harvard Medical School feature on this research (external link) .

At the bottom, the graphic repeats his role and contact information: “Gord Fishell, Ph.D., Professor of Neurobiology, Harvard Medical School”, with the email gordon_fishell@hms.harvard.edu and the lab website fishelllab.hms.harvard.edu .

Publications View
Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution.
Authors: Authors: Kim JH, Vlachos A, Mahadevan V, Caccavano AP, Banke T, Crawley OC, Navarro AI, Yuan X, Abebe D, Hunt S, Vargish GA, Chittajallu R, Eldridge MAG, Azadi R, Cummins AC, Tangen AC, Harmon P, Plotnikova A, Mohanty A, Furlanis E, Wang Y, Dai M, Garcia BL, Liu D, Zhu Z, Yuan H, Summer SL, Epplin MP, Liotta DC, Pickel J, Averbeck BB, Perez-Otaño I, Dimidschstein J, Fishell G, Traynelis SF, McBain CJ, Pelkey KA.
bioRxiv
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A novel and evolutionarily conserved inhibitory circuit selectively regulates dentate gyrus mossy cell function.
Authors: Authors: Vargish GA, Rice H, Yuan X, Hunt S, Caccavano AP, Hines BE, Plotnikova A, Mohanty A, Furlanis E, Wang Y, Dai M, Garcia BL, Cummins AC, Eldridge MAG, Averbeck BB, Zaghloul KA, Dimidschstein J, Fishell G, Pelkey KA, McBain CJ.
Res Sq
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A novel, evolutionarily conserved inhibitory circuit selectively regulates dentate gyrus mossy cell function.
Authors: Authors: Vargish GA, Rice H, Yuan X, Hunt S, Hines BE, Plotnikova A, Mohanty A, Furlanis E, Wang Y, Dai M, Garcia BL, Cummins AC, Eldridge MAG, Averbeck BB, Zaghloul KA, Dimidschstein J, Fishell G, Pelkey KA, McBain CJ.
bioRxiv
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Reciprocal interaction between cortical SST and PV interneurons in top-down regulation of retinothalamic refinement.
Authors: Authors: Jiang Q, Wu SJ, Fishell G, Chen C.
Proc Natl Acad Sci U S A
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Feature-specific threat coding in lateral septum guides defensive action.
Authors: Authors: Mazo DLB, Pasqualini AL, Wu SJ, Berger MZC, Reid CM, Brito SI, Qiu S, Levitt P, Anthony TE, Fishell G.
Res Sq
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Exploring brain circuits, one cell type-or more- at a time.
Authors: Authors: Tasic B, Fishell G.
Neuron
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An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes.
Authors: Authors: Furlanis E, Dai M, Leyva Garcia B, Tran T, Vergara J, Pereira A, Gorissen BL, Wills S, Vlachos A, Hairston A, Dwivedi D, Du S, McMahon J, Huang S, Morabito A, Vazquez A, Kim S, Lee AT, Chang EF, Razzaq T, Qazi A, Vargish G, Yuan X, Caccavano A, Hunt S, Chittajallu R, McLean N, Hewitt L, Paranzino E, Rice H, Cummins AC, Plotnikova A, Mohanty A, Tangen AC, Shin JH, Azadi R, Eldridge MAG, Alvarez VA, Averbeck BB, Alyahyay M, Vallejo TR, Soheib M, Vattino LG, MacGregor CP, Chatain CP, Banks E, Olah VJ, Naskar S, Hill S, Liebergall S, Badiani R, Hyde L, Hanley E, Xu Q, Allaway KC, Goldberg EM, Rowan MJM, Nowakowski TJ, Lee S, Favuzzi E, Kaeser PS, Sjulson L, Batista-Brito R, Takesian AE, Ibrahim LA, Iqbal A, Pelkey KA, McBain CJ, Dimidschstein J, Fishell G, Wang Y.
Neuron
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An anatomical and physiological basis for flexible coincidence detection in the auditory system.
Authors: Authors: Kreeger LJ, Honnuraiah S, Maeker S, Shea S, Fishell G, Goodrich L.
Elife
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Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development.
Authors: Authors: Caccavano AP, Vlachos A, McLean N, Kimmel S, Kim JH, Vargish G, Mahadevan V, Hewitt L, Rossi AM, Spineux I, Wu SJ, Furlanis E, Dai M, Leyva Garcia B, Wang Y, Chittajallu R, London E, Yuan X, Hunt S, Abebe D, Eldridge MAG, Cummins AC, Hines BE, Plotnikova A, Mohanty A, Averbeck BB, Zaghloul KA, Dimidschstein J, Fishell G, Pelkey KA, McBain CJ.
Neuron
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Differential behavioral engagement of inhibitory interneuron subtypes in the zebra finch brain.
Authors: Authors: Hozhabri E, Corredera Asensio A, Elmaleh M, Kim JW, Phillips MB, Frazel PW, Dimidschstein J, Fishell G, Long MA.
Neuron
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