Rosalind Segal

Rosalind Segal, M.D., Ph.D.

Professor of Neurobiology, Dana-Farber Cancer Institute
Dean for Graduate Education, Harvard Medical School
617-632-4737
Segal Lab Website

Intercellular Communication

Our research focuses on intercellular communication: how growth factor signaling pathways regulate brain development, and how these pathways contribute to abnormal proliferation, migration and survival in brain tumors and in other neurologic disorders.

Publications View
Polarized Signaling Endosomes Coordinate BDNF-Induced Chemotaxis of Cerebellar Precursors.
Authors: Authors: Zhou P, Porcionatto M, Pilapil M, Chen Y, Choi Y, Tolias KF, Bikoff JB, Hong EJ, Greenberg ME, Segal RA.
Neuron
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Satellite glial contact enhances differentiation and maturation of human iPSC-derived sensory neurons.
Authors: Authors: LeBlang CJ, Pazyra-Murphy MF, Silagi ES, Dasgupta S, Tsolias M, Miller T, Petrova V, Zhen S, Jovanovic VM, Castellano D, Gerrish K, Ormanoglu P, Tristan CA, Singeç I, Woolf CJ, Tasdemir-Yilmaz O, Segal RA.
Stem Cell Reports
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Association Between the CEP72 Genotype and Chemotherapy-Induced Peripheral Neuropathy Severity in Young Adults Receiving Vincristine or Paclitaxel.
Authors: Authors: Knoerl R, Mazzola E, Pazyra-Murphy MF, Frazier L, Freeman R, Hammer MJ, LaCasce AS, Ligibel J, Luskin MR, Berry DL, Segal RA.
Oncol Nurs Forum
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SMARCA5 is required for the development of granule cell neuron precursors and Sonic Hedgehog Medulloblastoma growth.
Authors: Authors: Tsiami F, Drwesh L, Surender S, Fitzgerald J, Schittenhelm J, Picketts DJ, Segal RA, Tabatabai G, Merk DJ.
Sci Rep
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Profiling local translatomes and RNA binding proteins of somatosensory neurons reveals specializations of individual axons.
Authors: Authors: Silagi ES, Nduka E, Pazyra-Murphy MF, Paiz JZ, Bhuiyan SA, Segal RA.
bioRxiv
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Exploring clinical markers of Axon degeneration processes in Chemotherapy-induced peripheral neuropathy among young adults receiving vincristine or paclitaxel.
Authors: Authors: Knoerl R, Mazzola E, Pazyra-Murphy M, Ryback B, Frazier AL, Freeman RL, Hammer M, LaCasce A, Ligibel J, Luskin MR, Berry DL, Segal RA.
BMC Neurol
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Satellite glial contact enhances differentiation and maturation of human iPSC-derived sensory neurons.
Authors: Authors: LeBlang CJ, Pazyra-Murphy MF, Silagi ES, Dasgupta S, Tsolias M, Miller T, Petrova V, Zhen S, Jovanovic V, Castellano D, Gerrish K, Ormanoglu P, Tristan C, Singeç I, Woolf CJ, Tasdemir-Yilmaz O, Segal RA.
bioRxiv
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Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma.
Authors: Authors: Tsiami F, Lago C, Pozza N, Piccioni F, Zhao X, Lülsberg F, Root DE, Tiberi L, Kool M, Schittenhelm J, Bandopadhayay P, Segal RA, Tabatabai G, Merk DJ.
Acta Neuropathol Commun
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Dissecting the neuroprotective interaction between the BH4 domain of BCL-w and the IP3 receptor.
Authors: Authors: Tang SX, Camara CM, Franco JA, Pazyra-Murphy MF, Li Y, Godes M, Moyer BM, Bird GH, Segal RA, Walensky LD.
Cell Chem Biol
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Satellite Glial Cells: No Longer the Most Overlooked Glia.
Authors: Authors: Birren SJ, Goodrich LV, Segal RA.
Cold Spring Harb Perspect Biol
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