Gord Fishell

Gord Fishell, Ph.D.

Professor of Neurobiology, Harvard Medical School

Accessible description of graphic: One-page profile titled “Gord Fishell, Ph.D.” with the subtitle “Professor of Neurobiology, Harvard Medical School.” At the top right is a portrait photo of Gord Fishell. Under the title there are two circular buttons: one linking to his email address and one to his laboratory website. The email button links to gordon_fishell@hms.harvard.edu and the lab button links to fishelllab.hms.harvard.edu .

Under the heading “The Aim”, the text reads: “The Fishell Lab investigates how inhibitory interneurons, the brain's primary gating system of information flow, are generated and integrated into circuits during development.”

Under the heading “The Impact”, the text explains that brain function depends on a balance between excitation and inhibition, and that inhibitory interneurons are responsible for maintaining that balance. The Fishell Lab’s research reveals a remarkable diversity of interneuron subtypes, each with its own shape, connectivity, and function. Mapping the developmental origins of interneuron diversity is opening new avenues for therapeutic approaches to conditions such as autism and schizophrenia.

A section titled “A Closer Look” highlights two featured studies. The first is labeled “Nature – May 2026” and is illustrated with a multipanel figure. The caption explains that this paper discusses new research that pinpoints a specific set of brain cells in mice that rapidly detect danger and convert signals from memory and emotion centers into defensive actions such as freezing or escaping. You can read this article at the related Nature publication (external link) .

The second featured item is labeled “Harvard Medical School – December 2021”, with an illustration titled “The Brain’s Wiring Technicians.” The text explains that Gord Fishell’s team discovered a specialized subset of microglia—immune cells in the brain—that home in on and selectively “prune” inhibitory synapses via GABA receptors. This pruning helps balance excitation and inhibition in developing circuits and suggests new ways to fix miswired brain networks in disorders such as autism, ADHD, and schizophrenia. A related article can be accessed at the Harvard Medical School feature on this research (external link) .

At the bottom, the graphic repeats his role and contact information: “Gord Fishell, Ph.D., Professor of Neurobiology, Harvard Medical School”, with the email gordon_fishell@hms.harvard.edu and the lab website fishelllab.hms.harvard.edu .

Publications View
Feature-specific threat coding in lateral septum guides defensive action.
Authors: Authors: Bhatti Mazo DL, Berger MZC, Pasqualini AL, Wu SJ, Reid CM, Brito SI, Qiu S, Levitt P, Anthony TE, Fishell G.
Nature
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Pyramidal neurons proportionately alter cortical interneuron subtypes.
Authors: Authors: Wu SJ, Dai M, Yang SP, McCann C, Qiu Y, Kumar V, Marrero GJ, Tsyporin J, Huang S, Shin D, Stogsdill JA, Di Bella DJ, Xu Q, Chen B, Farhi SL, Macosko EZ, Chen F, Fishell G.
Nature
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Developmental dysregulation of chandelier cell excitability in a mouse model of Dravet Syndrome.
Authors: Authors: Hill SF, Enakhimion EA, Furlanis E, Dai M, Garcia BL, Wills S, Tran T, Fishell G, Wang Y, Goldberg EM.
bioRxiv
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Non-reciprocal callosal projections and input gradients underlie interhemispheric communication in binocular visual cortex.
Authors: Authors: Honnuraiah S, Huang H, Furlanis E, Perumal MB, Ryan WJ, Broersen R, Connelly WM, Fishell G, Stuart GJ.
Cell Rep
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LARIS enables accurate and efficient ligand and receptor interaction analysis in spatial transcriptomics.
Authors: Authors: Dai M, Török T, Sun D, Shende V, Wang G, Lin Y, Wu SJ, Rukshin A, Fishell G, Chen F.
bioRxiv
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Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution.
Authors: Authors: Kim JH, Vlachos A, Mahadevan V, Caccavano AP, Banke TG, Crawley OC, Navarro AI, Yuan X, Abebe D, Hunt S, Vargish GA, Chittajallu R, Eldridge MAG, Azadi R, Cummins AC, Tangen AC, Harmon P, Plotnikova A, Mohanty A, Furlanis E, Wang Y, Dai M, Garcia BL, Liu D, Zhu Z, Yuan H, Summer SL, Epplin MP, Liotta DC, Pickel J, Averbeck BB, Pérez-Otaño I, Dimidschstein J, Fishell G, Traynelis SF, McBain CJ, Pelkey KA.
Res Sq
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Biologically grounded neocortex computational primitives implemented on neuromorphic hardware improve vision transformer performance.
Authors: Authors: Iqbal A, Mahmood H, Stuart GJ, Fishell G, Honnuraiah S.
Proc Natl Acad Sci U S A
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Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution.
Authors: Authors: Kim JH, Vlachos A, Mahadevan V, Caccavano AP, Banke T, Crawley OC, Navarro AI, Yuan X, Abebe D, Hunt S, Vargish GA, Chittajallu R, Eldridge MAG, Azadi R, Cummins AC, Tangen AC, Harmon P, Plotnikova A, Mohanty A, Furlanis E, Wang Y, Dai M, Garcia BL, Liu D, Zhu Z, Yuan H, Summer SL, Epplin MP, Liotta DC, Pickel J, Averbeck BB, Perez-Otaño I, Dimidschstein J, Fishell G, Traynelis SF, McBain CJ, Pelkey KA.
bioRxiv
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A novel and evolutionarily conserved inhibitory circuit selectively regulates dentate gyrus mossy cell function.
Authors: Authors: Vargish GA, Rice H, Yuan X, Hunt S, Caccavano AP, Hines BE, Plotnikova A, Mohanty A, Furlanis E, Wang Y, Dai M, Garcia BL, Cummins AC, Eldridge MAG, Averbeck BB, Zaghloul KA, Dimidschstein J, Fishell G, Pelkey KA, McBain CJ.
Res Sq
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A novel, evolutionarily conserved inhibitory circuit selectively regulates dentate gyrus mossy cell function.
Authors: Authors: Vargish GA, Rice H, Yuan X, Hunt S, Hines BE, Plotnikova A, Mohanty A, Furlanis E, Wang Y, Dai M, Garcia BL, Cummins AC, Eldridge MAG, Averbeck BB, Zaghloul KA, Dimidschstein J, Fishell G, Pelkey KA, McBain CJ.
bioRxiv
View full abstract on Pubmed