Flier

Jeffrey S. Flier, MD

Higginson Professor of Physiology and Medicine
Harvard University Distinguished Service Professor
Former Dean of the Faculty of Medicine (2007- 2016)
Publications View
Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling.
Authors: Authors: Shi H, Tzameli I, Bjørbaek C, Flier JS.
J Biol Chem
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Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.
Authors: Authors: Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjørbaek C, Flier JS.
Nat Med
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Adipose tissue as an endocrine organ.
Authors: Authors: Kershaw EE, Flier JS.
J Clin Endocrinol Metab
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Neuroscience. The fat-brain axis enters a new dimension.
Authors: Authors: Elmquist JK, Flier JS.
Science
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Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice.
Authors: Authors: Morton NM, Paterson JM, Masuzaki H, Holmes MC, Staels B, Fievet C, Walker BR, Flier JS, Mullins JJ, Seckl JR.
Diabetes
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Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain.
Authors: Authors: Kelly JF, Elias CF, Lee CE, Ahima RS, Seeley RJ, Bjørbaek C, Oka T, Saper CB, Flier JS, Elmquist JK.
Diabetes
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Obesity wars: molecular progress confronts an expanding epidemic.
Authors: Authors: Flier JS.
Cell
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Tissue-specific glucocorticoid reactivating enzyme, 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)--a promising drug target for the treatment of metabolic syndrome.
Authors: Authors: Masuzaki H, Flier JS.
Curr Drug Targets Immune Endocr Metabol Disord
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Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype.
Authors: Authors: Segal-Lieberman G, Bradley RL, Kokkotou E, Carlson M, Trombly DJ, Wang X, Bates S, Myers MG, Flier JS, Maratos-Flier E.
Proc Natl Acad Sci U S A
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Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice.
Authors: Authors: Masuzaki H, Yamamoto H, Kenyon CJ, Elmquist JK, Morton NM, Paterson JM, Shinyama H, Sharp MG, Fleming S, Mullins JJ, Seckl JR, Flier JS.
J Clin Invest
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