Corey Harwell
Corey Harwell, Ph.D.
Assistant Professor of Neurobiology

The goal of our work is to elucidate the cellular and molecular mechanisms that regulate the precise connectivity of the cortical network. Our cerebral cortex is responsible for regulating many of our most complex behaviors and cognitive functions. Our lab utilizes anatomy, genetics and electrophysiology to study both cell intrinsic and extrinsic factors that guide the formation of cortical circuits. Understanding the important molecules and developmental mechanisms critical for proper circuit formation will provide important insight into the etiology of complex neural developmental disorders such as autism and schizophrenia. Recently we showed that the secreted morphogen Sonic Hedgehog is expressed in specific populations of corticofugal projection neurons, while the Sonic Hedgehog receptor Boc is expressed in a complementary population of local and callosal projection neurons. Using anatomy and optogenetics we showed that Sonic Hedgehog and Boc function are required for the proper formation of layer II/III to layer V cortical connections. In the near term we plan to elucidate the cellular mechanism and signaling pathways that are involved in regulating Sonic Hedgehog mediated synapse formation through Boc. Our long-term goal is to identify the key molecules and cellular mechanisms that regulate the formation of connections between anatomically and molecularly defined populations of cortical neurons.

"Our lab utilizes anatomy, genetics and electrophysiology to study both cell intrinsic and extrinsic factors that guide the formation of cortical circuits."

Publications View
Sonic hedgehog signaling in astrocytes mediates cell-type-specific synaptic organization.
Authors: Authors: Hill SA, Blaeser AS, Coley AA, Xie Y, Shepard KA, Harwell CC, Gao WJ, Garcia ADR.
Elife
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The Elegance of Sonic Hedgehog: Emerging Novel Functions for a Classic Morphogen.
Authors: Authors: Garcia ADR, Han YG, Triplett JW, Farmer WT, Harwell CC, Ihrie RA.
J Neurosci
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The Epigenetic State of PRDM16-Regulated Enhancers in Radial Glia Controls Cortical Neuron Position.
Authors: Authors: Baizabal JM, Mistry M, García MT, Gómez N, Olukoya O, Tran D, Johnson MB, Walsh CA, Harwell CC.
Neuron
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The Epigenetic State of PRDM16-Regulated Enhancers in Radial Glia Controls Cortical Neuron Position.
Authors: Authors: Baizabal JM, Mistry M, García MT, Gómez N, Olukoya O, Tran D, Johnson MB, Walsh CA, Harwell CC.
Neuron
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Radial glia in the ventral telencephalon.
Authors: Authors: Turrero García M, Harwell CC.
FEBS Lett
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Lineage Relationships Do Not Drive MGE/PoA-Derived Interneuron Clustering in the Brain.
Authors: Authors: Turrero García M, Mazzola E, Harwell CC.
Neuron
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Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons.
Authors: Authors: Harwell CC, Fuentealba LC, Gonzalez-Cerrillo A, Parker PR, Gertz CC, Mazzola E, Garcia MT, Alvarez-Buylla A, Cepko CL, Kriegstein AR.
Neuron
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Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation.
Authors: Authors: Harwell CC, Parker PR, Gee SM, Okada A, McConnell SK, Kreitzer AC, Kriegstein AR.
Neuron
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Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity.
Authors: Authors: Ihrie RA, Shah JK, Harwell CC, Levine JH, Guinto CD, Lezameta M, Kriegstein AR, Alvarez-Buylla A.
Neuron
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Regulation of cpg15 expression during single whisker experience in the barrel cortex of adult mice.
Authors: Authors: Harwell C, Burbach B, Svoboda K, Nedivi E.
J Neurobiol
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