Rosalind Segal

Rosalind Segal, MD, PhD

Professor of Neurobiology
617-632-4737
Segal Lab Website

Intercellular Communication

Our research focuses on intercellular communication: how growth factor signaling pathways regulate brain development, and how these pathways contribute to abnormal proliferation, migration and survival in brain tumors and in other neurologic disorders.

Publications View
A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas.
Authors: Authors: Sun Y, Alberta JA, Pilarz C, Calligaris D, Chadwick EJ, Ramkissoon SH, Ramkissoon LA, Garcia VM, Mazzola E, Goumnerova L, Kane M, Yao Z, Kieran MW, Ligon KL, Hahn WC, Garraway LA, Rosen N, Gray NS, Agar NY, Buhrlage SJ, Segal RA, Stiles CD.
Neuro Oncol
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Tyrosine receptor kinase B is a drug target in astrocytomas.
Authors: Authors: Ni J, Xie S, Ramkissoon SH, Luu V, Sun Y, Bandopadhayay P, Beroukhim R, Roberts TM, Stiles CD, Segal RA, Ligon KL, Hahn WC, Zhao JJ.
Neuro Oncol
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A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy.
Authors: Authors: Fukuda Y, Li Y, Segal RA.
Front Neurosci
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Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy.
Authors: Authors: Pak E, Segal RA.
Dev Cell
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There and back again: coordinated transcription, translation and transport in axonal survival and regeneration.
Authors: Authors: Tasdemir-Yilmaz OE, Segal RA.
Curr Opin Neurobiol
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Can the referring surgeon enhance accrual of breast cancer patients to medical and radiation oncology trials? The ENHANCE study.
Authors: Authors: Arnaout A, Kuchuk I, Bouganim N, Pond G, Verma S, Segal R, Dent S, Gertler S, Song X, Kanji F, Clemons M.
Curr Oncol
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The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability.
Authors: Authors: Cosker KE, Fenstermacher SJ, Pazyra-Murphy MF, Elliott HL, Segal RA.
Nat Neurosci
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Lessons from a bridge generation.
Authors: Authors: Segal RA.
Science
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How neuronal activity regulates glioma cell proliferation.
Authors: Authors: Filbin MG, Segal RA.
Neuro Oncol
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A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies.
Authors: Authors: Chadwick EJ, Yang DP, Filbin MG, Mazzola E, Sun Y, Behar O, Pazyra-Murphy MF, Goumnerova L, Ligon KL, Stiles CD, Segal RA.
J Vis Exp
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