Lisa Goodrich

Lisa Goodrich, PhD

Professor of Neurobiology
Department Vice Chair

Assembly and Function of Auditory Circuitry

Our auditory system allows us to hear the rich sounds of everyday life—music, the voices of friends and family, birdsongs—as well as sounds that cause alarm or signal danger. Crucial to the sense of hearing is the accurate wiring and function of the intricate neural circuitry within and between the ear and the brain. While much has been learned about the cellular and molecular building blocks underlying developmental processes from cell fate specification to synapse formation and refinement, we still do not fully understand how the specialized circuitry of the auditory system arises during development, matures and functions, and exhibits resiliency in the face of stressors or aging.

To learn how auditory neural networks acquire their unique properties and function across the lifespan, the Goodrich lab employs mouse genetics, single cell sequencing, and sensitive anatomical analyses, together with timelapse imaging and physiological approaches. We investigate circuit assembly, maintenance, and function in the auditory system both in the ear and the auditory brainstem. Peripherally and centrally, specific classes of neurons acquire unique genetic identities, physiological properties, and elaborate morphologies and connectivity patterns that are appropriate for their role in the circuit. We are studying how these features develop, from the genetic and epigenetic programs underlying acquisition of spiral ganglion neuron subtype identity, to the development, maintenance, and degeneration of their specialized synapses that ensure rapid and reliable transmission from the inner ear to the brain. Within the brain, we are examining the molecular, genetic, and physiological properties of neurons that receive auditory information from the ear, as well as those that send signals to the ear and shape auditory function and responses to stressors, in part by interactions with the immune system.

Publications View
A transcriptomic taxonomy of mouse brain-wide spinal projecting neurons.
Authors: Authors: Winter CC, Jacobi A, Su J, Chung L, van Velthoven CTJ, Yao Z, Lee C, Zhang Z, Yu S, Gao K, Duque Salazar G, Kegeles E, Zhang Y, Tomihiro MC, Zhang Y, Yang Z, Zhu J, Tang J, Song X, Donahue RJ, Wang Q, McMillen D, Kunst M, Wang N, Smith KA, Romero GE, Frank MM, Krol A, Kawaguchi R, Geschwind DH, Feng G, Goodrich LV, Liu Y, Tasic B, Zeng H, He Z.
Nature
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Control of T-shaped Bifurcation by Multiple Guidance Mechanisms during Dorsal Funiculus Development in the Spinal Cord.
Authors: Authors: Curran BM, Nickerson KR, Yung AR, Goodrich LV, Jaworski A, Tessier-Lavigne M, Ma L.
bioRxiv
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High temporal frequency light response in mouse retina is mediated by ON and OFF bipolar cells and requires FAT3 signaling.
Authors: Authors: Avilés EC, Wang SK, Patel S, Shi S, Lin L, Kefalov VJ, Goodrich LV, Cepko CL, Xue Y.
bioRxiv
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Experience-dependent flexibility in a molecularly diverse central-to-peripheral auditory feedback system.
Authors: Authors: Frank MM, Sitko AA, Suthakar K, Torres Cadenas L, Hunt M, Yuk MC, Weisz C, Goodrich LV.
Elife
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Runx1 controls auditory sensory neuron diversity in mice.
Authors: Authors: Shrestha BR, Wu L, Goodrich LV.
Dev Cell
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Fat3 acts through independent cytoskeletal effectors to coordinate asymmetric cell behaviors during polarized circuit assembly.
Authors: Authors: Avilés EC, Krol A, Henle SJ, Burroughs-Garcia J, Deans MR, Goodrich LV.
Cell Rep
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Diversity of developing peripheral glia revealed by single-cell RNA sequencing.
Authors: Authors: Tasdemir-Yilmaz OE, Druckenbrod NR, Olukoya OO, Dong W, Yung AR, Bastille I, Pazyra-Murphy MF, Sitko AA, Hale EB, Vigneau S, Gimelbrant AA, Kharchenko PV, Goodrich LV, Segal RA.
Dev Cell
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Making sense of neural development by comparing wiring strategies for seeing and hearing.
Authors: Authors: Sitko AA, Goodrich LV.
Science
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Sex-specific role for dopamine receptor D2 in dorsal raphe serotonergic neuron modulation of defensive acoustic startle and dominance behavior.
Authors: Authors: Lyon KA, Rood BD, Wu L, Senft RA, Goodrich LV, Dymecki SM.
eNeuro
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Neuronal processes and glial precursors form a scaffold for wiring the developing mouse cochlea.
Authors: Authors: Druckenbrod NR, Hale EB, Olukoya OO, Shatzer WE, Goodrich LV.
Nat Commun
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