Portrait of a woman with shoulder-length wavy brown hair, wearing a dark blue top, against a softly blurred indoor background.

Lisa Goodrich, Ph.D.

Professor of Neurobiology, Harvard Medical School
Vice Chair of Neurobiology, Harvard Medical School

Lisa Goodrich, PhD – People Feature

Professor of Neurobiology and Department Vice Chair in the Department of Neurobiology at Harvard Medical School.

If you prefer, you can view the visual layout directly on Canva by Neuro Coordinator.

Contact

Email: lisa_goodrich@hms.harvard.edu

Goodrich Lab website: goodrich.med.harvard.edu

The Goal

The Goodrich Lab studies how hearing circuits form and function, and what leads to their deterioration.

The Impact

Studying how the brain and ear work together to produce our sense of hearing offers insight into a key sensory system that people and animals use to navigate the world.

Hearing can be impaired by genetic mutations, infection, or exposure to excessively loud sounds. Deciphering the cellular and molecular mechanisms underlying the formation and function of auditory circuits may lead to improved protection of hearing and treatments for hearing loss.

This work has the potential to help people of all ages more fully enjoy the sounds that enrich our lives.

A Closer Look

Harvard Medicine Magazine — Spring 2020: 5 Questions with a Neurobiologist: A Conversation with Lisa Goodrich

Lisa reflects on the rewards and challenges of life as a researcher and offers advice for others interested in pursuing scientific research. She discusses the molecular origins of sensory circuits, the rewards of scientific discovery, and the importance of flexibility in research and career paths.

Harvard Medical School News — November 2011: Bioengineering for Hearing, Sight and Mobility

Dr. Goodrich presented her research at the inaugural Bertarelli Neuroengineering Symposium in Lausanne, Switzerland. Support from the Bertarelli Foundation funded a project in her lab with the potential to help people whose lives are affected by hearing loss.

The featured research focuses on understanding auditory hair cells and developing approaches that could support improved treatments for hearing loss.

Publications View
Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice.
Authors: Authors: Franco JA, Copeland TG, Merrow RD, Goodrich LV.
Nat Commun
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Modularity in the DCC extracellular domain elicits distinct effects on axon guidance.
Authors: Authors: Avilés EC, DeLoughery Z, Yung A, Wang JH, Meijers R, Goodrich L.
bioRxiv
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Developmental Neuroscience in the 21st Century.
Authors: Authors: Goodrich L, Shi SH.
Curr Opin Neurobiol
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Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice.
Authors: Authors: Goodrich L, Franco J, Copeland T, Merrow R.
Res Sq
View full abstract on Pubmed
Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice.
Authors: Authors: Franco JA, Copeland TG, Merrow RD, Goodrich LV.
bioRxiv
View full abstract on Pubmed
Combinatorial transcriptional regulation establishes subtype-appropriate synaptic properties in auditory neurons.
Authors: Authors: Bastille I, Lee L, Moncada-Reid C, Yu WM, Sitko A, Yung A, Zamani M, Christophersen N, Maroofian R, Galehdari H, Babai N, Vona B, Moser T, Goodrich L.
Cell Rep
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An anatomical and physiological basis for flexible coincidence detection in the auditory system.
Authors: Authors: Kreeger LJ, Honnuraiah S, Maeker S, Shea S, Fishell G, Goodrich L.
Elife
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ERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells.
Authors: Authors: Avilés EC, Wang SK, Patel S, Cordero S, Shi S, Lin L, Kefalov VJ, Goodrich LV, Cepko CL, Xue Y.
J Gen Physiol
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Lateral olivocochlear neurons modulate cochlear responses to noise exposure.
Authors: Authors: Sitko AA, Frank MM, Romero GE, Hunt M, Goodrich LV.
Proc Natl Acad Sci U S A
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The auditory midbrain mediates tactile vibration sensing.
Authors: Authors: Huey EL, Turecek J, Delisle MM, Mazor O, Romero GE, Dua M, Sarafis ZK, Hobble A, Booth KT, Goodrich LV, Corey DP, Ginty DD.
Cell
View full abstract on Pubmed